Trial DesignCharacteristics and outcomes of patients hospitalized for heart failure in the United States: Rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE)
Section snippets
Methods
ADHERE is a large, multicenter registry designed to compile a large clinical database on the clinical characteristics, management, and outcomes of patients hospitalized for heart failure across the United States. Data are collected on the episode of hospitalization beginning with the point of initial care and ending with the patient's discharge, transfer out of the hospital, or inhospital death. The ADHERE is sponsored by the biopharmaceutical company Scios, Inc (Fremont, Calif).
Results
The ADHERE was open for enrollment in late September 2001. Several participating sites received IRB approval to include discharges as far back as January 2001. As of January 4, 2004, 107 362 patients have been enrolled at 282 sites (Figure 3). This report is based on analysis of 105 388 patients from 274 hospitals with finalized data.
The mean age of patients was 72.4 (±14.0) years and 52% were women. Most patients were white (72%) or black (20%) and were covered by Medicare or Medicaid (78%).
Discussion
The characteristics and outcomes of patients with acutely decompensated heart failure are poorly defined currently despite the public health importance of this syndrome. The ADHERE, developed to better characterize this population, is the first diverse, large-scale, prospective multicenter database of patients hospitalized for heart failure. Progress in ADHERE to date demonstrates the feasibility of a registry program to describe patients admitted to the hospital with heart failure. Enrollment
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The ADHERE Scientific Advisory Committee members are listed in Appendix A.