General Pharmacology: The Vascular System
ReviewPharmacological aspects of pentoxifylline with emphasis on its inhibitory actions on hepatic fibrogenesis☆
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Therapeutic considerations for prevention and treatment of thrombotic events in COVID-19
2023, Thrombosis UpdateCitation Excerpt :Suppression of neutrophil activation with amplification of IL-10 by pentoxifylline protects against endothelial damage and development of a nidus for coagulation. When modulating leukocyte-endothelium adhesion with complete inhibition of intercellular adhesion molecule-1 expression, it sufficiently regulates leukocyte-platelet interactions relevant in thrombosis [75]. A study of the use of pentoxifylline for lysis of intraperitoneal adhesions in rats demonstrated increased levels and activity of tissue plasminogen activator when compared with a control group [76].
Molecular modeling studies of fused pyrimidine derivatives at various receptors
2022, Fused Pyrimidine-Based Drug DiscoveryPhosphodiestrase-1 and 4 inhibitors ameliorate liver fibrosis in rats: Modulation of cAMP/CREB/TLR4 inflammatory and fibrogenic pathways
2019, Life SciencesCitation Excerpt :Therefore, examining the effect of certain PDE inhibitors in liver fibrosis seemed appealing especially that limited data studying the role of PDEs in the pathogenesis of liver fibrosis are available. Research conducted on PDE inhibitors proved their beneficial effect in experimental liver injuries [14–16]. Among these inhibitors are vinpocetine which is PDE1 inhibitor and roflumilast, a PDE4 inhibitor.
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We are grateful to Dr. Georg Kirchner, Department of Clinical Chemistry, Philipps-University of Marburg, for reading the manuscript.