Original articlesCapsaicin inhibits the voltage-operated calcium channels intracellularly in the antral circular myocytes of guinea-pig stomach
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A novel form of capsaicin-modified amygdala LTD mediated by TRPM1
2016, Neurobiology of Learning and MemoryCitation Excerpt :These results support the conclusion that TRPV1 activation is not necessary for the capsaicin-induced modification of PP-LFS-induced LA-LTD. Because LA-LTD induction should require moderate postsynaptic depolarization and capsaicin can also act on calcium channels (Kopanitsa, Panchenko, Magura, Lishko, & Krishtal, 1995; Sim et al., 2001), we examined the potential contribution of calcium influx via L-type voltage-gated Ca2+ channels. We have previously shown that LFS-induced LA-LTD can be modified by L-type calcium channels (Tchekalarova & Albrecht, 2007).
Vasorelaxation to capsaicin and its effects on calcium influx in arteries
2012, European Journal of PharmacologyCitation Excerpt :Sim et al. (2001) demonstrated that capsaicin dose-dependently relaxed antral circular myocytes from the guinea pig stomach. It was also shown that capsaicin produced similar inhibitory effects to calcium channel antagonists and caused relaxations by blocking voltage operated calcium channels (Fujimoto and Mori, 2004; Sim et al., 2001). It was concluded that capsaicin was acting on intracellular stores of calcium.
Cannabinoid 1 receptor activation inhibits transient receptor potential vanilloid type 1 receptor-mediated cationic influx into rat cultured primary sensory neurons
2009, NeuroscienceCitation Excerpt :Cobalt ions can enter cells only through ligand-gated Ca2+ channels including TRPV1 (Pruss et al., 1991; Nagy et al., 1993; Hack and Balazs, 1995; Zhou et al., 1995). Capsaicin below 1 μM is known to activate only TRPV1 (Baker and Ritchie, 1994; Lo et al., 1995; Sim et al., 2001; Lundbaek et al., 2005; Athanasiou et al., 2007; Wang et al., 2007). Thus, in our study cobalt influx had to be mediated only through TRPV1.
Receptor-independent actions of cannabinoids on cell membranes: Focus on endocannabinoids
2006, Pharmacology and TherapeuticsCapsaicin-induced, capsazepine-insensitive relaxation of the guinea-pig ileum
2006, European Journal of PharmacologyCapsaicin differentially modulates voltage-activated calcium channel currents in dorsal root ganglion neurones of rats
2005, Brain ResearchCitation Excerpt :While the amount of calcium entering through the TRPV1 associated pore was relatively low in voltage-clamp experiments at −80 mV [40], larger amounts of extracellular calcium may enter the cell when voltage-activated calcium channels (VACCs) are activated, e.g., by action potential discharges [17]. It has been shown that capsaicin directly blocks calcium entry through voltage-activated calcium channels in a variety of different cell types [25,33] with effective concentrations between 5.8 μM and 20 μM (IC50 values [25]), while it seems to be highly effective in sensory neurones at a concentration of 1 μM [38]. It has also been shown that capsaicin (30 μM) shifts the current–voltage relation of voltage-activated calcium channels to the hyperpolarizing range [30], indicating a facilitated activation of these channels with smaller depolarizations.