Original Articles
Incidence of atrial flutter/fibrillation in adults with atrial septal defect before and after surgery

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Abstract

Background. There is controversy about the benefit of surgical repair for atrial septal defect in adults, especially its effect on the incidence of supraventricular dysrhythmias, atrial flutter and fibrillation. We studied their incidence before and after operation.

Methods. We examined surface and 24-hour Holter electrocardiograms before, early (between 3 and 7 days), and late (more than 6 months) after operation, performed at age 42.2 years (range, 18.5 to 74.9 years), in 211 adults with atrial septal defect. Patients were arbitrarily divided into three groups: age 18 to 40 years (n = 101), age 40 to 60 years (n = 83), and age more than 60 years (n = 27). All consecutive patients operated on between January 1988 and December 1996 and having a pulmonary to systemic flow ratio of 1.5:1 or greater were included in this study.

Results. The age of patients without arrhythmias before or after atrial septal defect closure (39 ± 13 years) was significantly lower than that of patients with flutter (54 ± 12 years) or fibrillation (59 ± 8 years). The incidence of atrial flutter was influenced by surgical repair as atrial flutter converted to sinus rhythm late after operation in 10 of 18 patients. However, there was no change in the incidence of atrial fibrillation before (n = 28) and after (n = 21) operation.

Conclusions. Our data show that surgical correction of atrial septal defect leads to regression of the incidence of atrial flutter but not fibrillation. Thus, surgical repair of atrial septal defect to abolish supraventricular tachyarrhythmias in adults is warranted, but in patients with fibrillation, it may have to be combined with a Maze operation in the future.

Section snippets

Patients and methods

Between January 1988 and December 1996, 211 consecutive patients older than 18 years of age underwent surgical closure of an atrial septal defect at the Deutsches Herzzentrum, Berlin. Every consecutive adult patient with a preoperative pulmonary to systemic flow (Qp/Qs) ratio of 1.5:1 or more was included in this study on the basis that he or she had situs solitus, concordant atrioventricular and ventriculoarterial connections, and an atrial septal defect (n = 185) in the fossa ovalis

Results

There was a significant improvement (p = 0.001) in NYHA functional class after surgical closure of the atrial septal defect. There was 1% mortality with 2 deaths within 30 days of operation in patients aged 57 and 68 years. The 57-year-old patient with pulmonary hypertension (mean pulmonary artery pressure, 68 mm Hg) died of a pulmonary hypertensive crisis 8 hours after the operation. She was operated on because at the preceding cardiac catheterization she was found to respond to a combination

Comment

Our data show that the presence or absence of atrial flutter/fibrillation may be a determinant of the maintenance of sinus rhythm after operation, and that the prevalence of preoperative supraventricular tachyarrhythmias increases with age. An important result of this study is that return to sinus rhythm from preoperative atrial flutter is possible, but unlikely if fibrillation is present. Thus in the future, patients with fibrillation should be managed differently, because closure of the

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