Clinical studyPrevalence of coronary heart disease associated with HFE mutations in adults attending a health appraisal center☆
Section snippets
Subjects and methods
The sample consisted of 30,916 white, non-Hispanic, adult patients aged 25 to 98 years who were attending the Health Appraisal Center at Kaiser Permanente, San Diego, California. All subjects gave informed consent to be screened for hemochromatosis by HFE genotyping. During any given 4-year period, approximately 81% of Kaiser enrollees attend the center; all patients attending were offered the opportunity to participate in the study. Those who consented represented 46% of all white,
Results
The sample consisted of 15,362 men (49.7%) and 15,554 women (Table 1). Mean transferrin saturation and ferritin levels varied by HFE genotype, with highest values occurring in C282Y homozygotes (C282Y/C282Y), followed by compound heterozygotes (C282Y/H63D), H63D homozygotes (H63D/H63D), C282Y heterozygotes (C282Y/wt), H63D heterozygotes (H63D/wt), and wild types (wt/wt) in both men and women (Table 1).
The overall prevalence of coronary heart disease was 12% (n = 1798) among men and 7% (n =
Discussion
In this large cross-sectional study of more than 30,000 white adults attending a health appraisal center, we found an increased odds of coronary heart disease among only one of 10 HFE genotype groups compared with sex-specific wild-type controls: male compound heterozygotes (C282Y/H63D) had a 1.6-fold increased odds of coronary heart disease after adjusting for age and other known cardiovascular risk factors. There were no significant associations among pooled carriers of the C282Y or the H63D
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Common Functional Genetic Variants in Catecholamine Storage Vesicle Protein Promoter Motifs Interact to Trigger Systemic Hypertension
2010, Journal of the American College of Cardiology
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Supported by grants DK53505-02 and RR00833 from the National Institutes of Health, Bethesda, Maryland, and supplemented with a grant from the Division of Nutrition and Physical Activity, Centers for Disease Control and Prevention, Atlanta, Georgia, and funds from the Stein Endowment Fund, San Diego, California.