Fish Consumption, n-3 Fatty Acids in Cell Membranes, and Heart Rate Variability in Survivors of Myocardial Infarction With Left Ventricular Dysfunction
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Acknowledgements
This study was supported by The Medical Research Foundation of the County of Northern Jutland and Aalborg Stifts Julelotteri.
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2014, Pharmacology and TherapeuticsCitation Excerpt :The anti-thrombotic properties of EPA and DHA, as well as CLA, have been attributed to their incorporation into platelet phospholipids at the expense of, for example AA, which is the precursor for the pro-aggregatory TxA2 (Al-Madaney et al., 2003; Smith, 2005). Indeed, the production of TxA2 from platelets stimulated by a variety of agonists decreased by 60% to 80% after EPA and DHA supplementation, both in vitro and in vivo (Siess et al., 1980; Goodnight, 1986; Kristensen et al., 1989; Weber, 1989; Christensen et al., 1997). In this respect, differential effects of EPA and DHA have been observed in various studies.
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