Elsevier

The Lancet

Volume 342, Issue 8879, 30 October 1993, Pages 1085-1086
The Lancet

Short reports
Angiotensin-converting enzyme polymorphism in hypertrophic cardiomyopathy and sudden cardiac death

https://doi.org/10.1016/0140-6736(93)92064-ZGet rights and content

Abstract

We determined the distribution frequency of angiotensin converting enzyme (ACE) polymorphism in 100 patients with hypertrophic cardiomyopathy and 106 of their unaffected siblings and offspring. The distribution of ACE genotypes was different in the two groups: allele D frequency of 0·69 in patients and 0·57 in relatives (p=0·021). The frequency of allele D was also higher in hypertrophic cardiomyopathy families with a high incidence of sudden cardiac death than those with a low incidence (0·74 vs 0·55, p=0·011). In 25 hypertrophic cardiomyopathy patients with a strong family history of sudden cardiac the frequency of allele D was 0·82 (p=0·001 vs normals). Lancet 1993; 342: 1085–86

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