Long-term hypertriglyceridemia and glucose intolerance in rats fed chronically an isocaloric sucrose-rich diet☆
References (46)
- et al.
Studies of the mechanisms of carbohydrate-induced lipemia in normal man
Atherosclerosis
(1973) - et al.
Induction of hypertriglyceridemia by fructose in rat
Life Sci
(1965) - et al.
Effect of fructose feeding on insulin secretion and insulin action in the rat
Metabolism
(1980) - et al.
Mechanism of carbohydrate-induced hypertriglyceridemia: Plasma lipid metabolism in mice
Metabolism
(1980) - et al.
Effect of glucose and fructose administration on lipid metabolism in the rat
J Nutr
(1968) - et al.
Characterization of a model of dietary induced hypertriglyceridemia in young non-obese rats
J Lipid Res
(1979) - et al.
Insulin and glucose responses in rats fed sucrose or starch
Am J Clin Nutr
(1979) - et al.
Selective measurement of two different triglyceride lipase activities in rat post-heparin plasma
J Lipid Res
(1973) Photometric adaptation of Somogyi method for determination of glucose
J Biol Chem
(1944)A rapid enzymic method for glycogen estimation in very small tissue samples
Clin Chim Acta
(1970)
Protein measurement with the folin phenol reagent
J Biol Chem
Regulation of lipoprotein lipase: Induction by insulin
Biochim Biophys Acta
Mechanism of insulin resistance in fructose-fed rats
Metabolism
Ability of exercise to inhibit carbohydrate-induced hypertriglyceridemia in rats
Metabolism
Long-term effect of moderate fructose feeding on glucose tolerance parameters in rats
J Nutr
Effect of isocaloric exchange of dietary starch and sucrose in humans on the gastric inhibitory polypeptide response to a sucrose load
Am J Clin Nutr
Carbohydrate induced and fat lipemia
Trans Assoc Am Physicians
Diabetic hypertriglyceridemia in the rat: animal models stimulating the syndromes of impaired glucose tolerance non-insulin dependent diabetes, and insulin dependent diabetes
Effect of different levels of protein in sucrose and starch diets on lipid synthesis in the rat
Isr J Med Sci
Post-heparin plasma hepatic triglycerides lipase and monoglyceride hydrolase activities in hyperlipemia induced by a sucrose-rich diet
Biomed Pharmacother
Effect of sucrose diet on insulin secretion in vivo and in vitro and on triglyceride storage and mobilisation of the heart of rats
Horm Metab Res
Effect of sucrose and fructose on carbohydrate and lipid metabolism and the resulting consequences
Long-term effects of moderate fructose feeding on lipogenic parameters in Wistar rats
Nutr Rep Int
Cited by (79)
Family history of diabetes determines the association of HOMA-IR with fasting and postprandial triglycerides in individuals with normal glucose tolerance
2021, Journal of Clinical LipidologyCitation Excerpt :Also, an earlier experimental study in rats carried out by our group reported that postprandial hypertriglyceridemia precedes to insulin resistance and type 2 diabetes mellitus using diet induced models of type 2 diabetes.19 Furthermore, some experimental studies also show that correction of postprandial hypertriglyceridemia could improve insulin sensitivity20,21 and that its containment with pharmacological agents did not allow insulin resistance and glucose intolerance to develop.19 Despite all this evidence, it is still not clear whether fasting or postprandial triglycerides contribute to the increased risk of diabetes in humans with a positive family history of diabetes.
Salvia hispanica L. and its therapeutic role in a model of insulin resistance
2020, Diabetes: Oxidative Stress and Dietary AntioxidantsAge-related periodontitis and alveolar bone loss in rice rats
2017, Archives of Oral BiologyThe Evidence for Saturated Fat and for Sugar Related to Coronary Heart Disease
2016, Progress in Cardiovascular DiseasesCitation Excerpt :Among the sugars, the monosaccharide, fructose, and the disaccharide, sucrose (fructose + glucose), seem to be of greater concern than glucose alone (as a monosaccharide, or as a polysaccharide in starch). The fructose-containing sugars seem to cause greater derangement when it comes to elevated insulin levels,56,65,66 reduced insulin sensitivity,67–71 increased fasting glucose concentrations,72,73 and increased glucose and insulin responses to a sucrose load.56,65 Providing liquid fructose supplementation to a western-type diet in mice increases lipid burden and atherosclerosis despite identical calorie consumption.74
Added Fructose: A Principal Driver of Type 2 Diabetes Mellitus and Its Consequences
2015, Mayo Clinic ProceedingsCitation Excerpt :Replacing starch (an all-glucose polymer) with sucrose (glucose and fructose) increases fasting insulin, reduces insulin sensitivity, and leads to increased glucose concentrations.54-60 The change also leads to a variety of other undesirable metabolic effects, including increased cholesterol, apolipoprotein B, triglycerides, adipose storage, and blood pressure.54-60 Trials looking at isolated fructose (vs starch or glucose) reveal the same derangements, supporting the notion that fructose is the likely component of sucrose that causes the adverse metabolic effects.42,52,61-63
- ☆
Supported by CONICET (Consejo Nacional de Investigaciones Cientificas y Tecnológicas), Argentina by Grant 0088/85, and with financial aid from A.J. Roemmers Foundation for Biochemistry Research, Argentina.