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Coronary Vasomotion One Year after Drug-Eluting Stent Implantation: Comparison of Everolimus-Eluting and Paclitaxel-Eluting Coronary Stents

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Abstract

First-generation drug-eluting stents (DES) have been associated with impaired localized coronary vasomotion and delayed endothelialization. We aimed to compare coronary vasomotion after implantation of a newer-generation everolimus-eluting stent (EES), with a first-generation paclitaxel-eluting stent (PES). Coronary vasomotion was studied in 19 patients with EES and 13 with PES. Vasomotor response was measured proximally and distally to the stent and in a remote vessel (reference segment). Quantitative coronary angiography was performed offline. Endothelium independent vasomotion did not differ significantly between the two groups. EES showed significant vasodilatation while PES showed vasoconstriction at both proximal (+4.5 ± 3.6 vs −4.2 ± 6.9, p < 0.001) and distal (+4.6 ± 7.9 vs −4.8 ± 9.3, p = 0.003) segments. The reference segment did not show any significant difference in vasodilatation between the two groups (+9.8 ± 6.4 vs +7.2 ± 5.2, p = 0.17). Endothelium-dependent vasomotion at adjacent stent segments is relatively preserved after EES implantation while vasoconstriction was observed after PES implantation.

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Acknowledgments

We would like to thank all interventional cardiologists and staff at the participating sites for contributing in one way or the other to this study. Dr. Dragica Paunovic has been instrumental in initiating and supporting the joint research programs between Aalst and Belgrade.

Funding Sources

This work was supported in part by the Meijer Lavino Foundation for Cardiac Research.

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Correspondence to William Wijns.

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Associate Editor Angela Taylor oversaw the review of this article

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Hamilos, M., Ribichini, F., Ostojic, M.C. et al. Coronary Vasomotion One Year after Drug-Eluting Stent Implantation: Comparison of Everolimus-Eluting and Paclitaxel-Eluting Coronary Stents. J. of Cardiovasc. Trans. Res. 7, 406–412 (2014). https://doi.org/10.1007/s12265-014-9568-2

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  • DOI: https://doi.org/10.1007/s12265-014-9568-2

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