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CHADS2 and CHA2DS2-VASc scores are independently associated with incident atrial fibrillation: the Catanzaro Atrial Fibrillation Project

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Abstract

No data exist concerning a possible association between CHADS2 or CHA2DS2-VASc scores and atrial fibrillation (AF). In this prospective observational study, we tested the hypothesis whether thromboembolic risk scores predict AF. We investigated 3549 subjects, 1829 men and 1720 women, aged 60.7 ± 10.6 years, without baseline AF. Patients with thyroid disorders were excluded. CHADS2 and CHA2DS2-VASc scores were evaluated as categorical variables. To test the effect of some clinical confounders on incident AF, we constructed different models including clinical and laboratory parameters. During follow-up (53.3 ± 18.1 months), 546 subjects developed AF (4.5 events/100 patient-years). Progressors to AF are older, have a higher body mass index (BMI), blood pressure, LDL-cholesterol, and glucose. Hypertension, metabolic syndrome, diabetes and carotid wall thickening were more common among AF cases than among control subjects. In the final Cox-regression model, variables that remained significantly associated with incident AF were BMI (HR = 1.022, 95 % CI = 1.008–1.037), LDL-cholesterol (HR = 1.032, 95 % CI = 1.008–1.056), CHA2DS2-VASc score (HR = 1.914, 95 % CI = 1.439–2.546), and CHADS2 score (HR = 2.077, 95 % CI = 1.712–2.521). In conclusion, CHADS2 and CHA2DS2-VASc scores are independent predictors of AF.

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Statement of human and animal rights

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study

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    Authors and Affiliations

    1. Department of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, Campus Universitario di Germaneto, V.le Europa, 88100, Catanzaro, Italy

      Angela Sciacqua, Eliezer J. Tassone, Antonio Cimellaro, Deborah Mazzaferro, Giorgio Sesti & Francesco Perticone

    2. Department of Clinical and Experimental Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy

      Maria Perticone

    3. Consiglio Nazionale delle Ricerche, Istituto di Biomedicina, Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension, Reggio Calabria, Italy

      Giovanni Tripepi

    Authors
    1. Angela Sciacqua
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    2. Maria Perticone
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    3. Giovanni Tripepi
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    4. Eliezer J. Tassone
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    5. Antonio Cimellaro
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    6. Deborah Mazzaferro
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    7. Giorgio Sesti
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    8. Francesco Perticone
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    Correspondence to Francesco Perticone.

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    A. Sciacqua and M. Perticone have equally contributed to the work.

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    Sciacqua, A., Perticone, M., Tripepi, G. et al. CHADS2 and CHA2DS2-VASc scores are independently associated with incident atrial fibrillation: the Catanzaro Atrial Fibrillation Project. Intern Emerg Med 10, 815–821 (2015). https://doi.org/10.1007/s11739-015-1243-3

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    • DOI: https://doi.org/10.1007/s11739-015-1243-3

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