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Role of interleukin-6 in regulation of immune responses to remodeling after myocardial infarction

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Abstract

Myocardial remodeling following myocardial infarction (MI) is emerging as key causes of chronic infarct mortality. Interleukin-6 is a classic pro-inflammatory cytokine needed to mount an effective immune response. It seems that interleukin-6 acts as an important role in the dynamic and superbly orchestrated process of innate immunity after MI. Interleukin-6 timely suppresses of innate immune signals to prevent the catastrophic consequences of uncontrolled inflammation on cardiac geometry and function, and thus tunes myocardial remodeling. A comprehensive understanding of biological processes of interleukin-6 in innate immunity leading to inflammatory response and disease-related ventricular remodeling is helpful to find the solution of chronic heart failure. To accomplish this, we reviewed the articles of interleukin-6 regard to inflammation, innate immunity, and cardiac remodeling. This review focuses on the role of interleukin-6 that dominates cell-mediated immunity, especially on neutrophils, monocytes, macrophages, and fibroblasts. In addition, we will also briefly discuss other inflammatory cytokines involved in this process within the paper.

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Acknowledgments

We thank Kunshi Yang for editing the figures. This study was supported by grants from the National Natural Science Foundation of China to Xiang Meixiang (No.81270127), and by National Science and Technology Major Project of China to Wang Jianan (No.2011ZX09302-002-02).

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  1. Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Province, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China

    Mingyuan Huang, Du Yang, Meixiang Xiang & Jianan Wang

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  1. Mingyuan Huang
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  2. Du Yang
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Correspondence to Meixiang Xiang.

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Huang, M., Yang, D., Xiang, M. et al. Role of interleukin-6 in regulation of immune responses to remodeling after myocardial infarction. Heart Fail Rev 20, 25–38 (2015). https://doi.org/10.1007/s10741-014-9431-1

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