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Iron deficiency anemia in heart failure

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Abstract

Anemia and iron deficiency are quite prevalent in patients with heart failure (HF) and may overlap. Both anemia and iron deficiency are associated with worse symptoms and adverse clinical outcomes. In the past few years, there has been an enormous interest in the subject of iron deficiency and its management in patients with HF. In this review, the etiology and relevance of iron deficiency, iron metabolism in the setting of HF, studies on iron supplementation in patients with HF and potential cardiovascular effects of subclinical iron overload are discussed.

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Acknowledgments

Dr. Jalal K. Ghali has received research grants from Amgen and serves on the steering committee of RED-HF trial.

Conflict of interest

Dr. Natasha P. Arora has no conflicts of interest or financial ties to disclose.

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  1. Detroit Medical Center, Wayne State University, Detroit, MI, USA

    Natasha P. Arora

  2. DMC Cardiovascular Institute, Wayne State University, 3990 John R, Suite 9370, Detroit, MI, 48201, USA

    Jalal K. Ghali

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  1. Natasha P. Arora
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Correspondence to Jalal K. Ghali.

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Arora, N.P., Ghali, J.K. Iron deficiency anemia in heart failure. Heart Fail Rev 18, 485–501 (2013). https://doi.org/10.1007/s10741-012-9342-y

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