Skip to main content
Log in

Glucagon Like Peptide-1 is Protective Against Myocardial Ischemia/Reperfusion Injury when Given Either as a Preconditioning Mimetic or at Reperfusion in an Isolated Rat Heart Model

  • Short Communication
  • Published:
Cardiovascular Drugs and Therapy Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Brubaker PL, Drucker DJ. Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system. Endocrinology 2004; 145(6):2653–2659.

    Article  CAS  PubMed  Google Scholar 

  2. Luque MA, Gonzalez N, Marquez L, et al. Glucagon-like peptide-1 (GLP-1) and glucose metabolism in human myocytes. J Endocrinol 2002;173(3):465–473.

    Article  CAS  PubMed  Google Scholar 

  3. Nikolaidis LA, Mankad S, Sokos GG, et al. Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation 2004;109(8):962–965.

    CAS  PubMed  Google Scholar 

  4. Huisamen B, Genade S, Lochner A. Glucagon-like peptide-1 (GLP-1) protects the heart against ischaemia by activating glycoclysis. Cardiovasc J S Afr 2004;15(4 Suppl 1): S15.

    CAS  Google Scholar 

  5. Kavianipour M, Ehlers MR, Malmberg K, et al. Glucagon-like peptide-1 (7-36) amide prevents the accumulation of pyruvate and lactate in the ischemic and non-ischemic porcine myocardium. Peptides 2003;24(4):569–578.

    CAS  PubMed  Google Scholar 

  6. Bose AK, Mocanu MM, Carr RD, Brand CL, Yellon DM. Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury. Diabetes 2005;54(1):146–151.

    CAS  PubMed  Google Scholar 

  7. Hausenloy DJ, Yellon DM. New directions for protecting the heart against ischaemia-reperfusion injury: Targeting the Reperfusion Injury Salvage Kinase(RISK)-pathway. Cardiovasc Res 2004;61(3):448–460.

    CAS  PubMed  Google Scholar 

  8. Mocanu MM, Bell RM, Yellon DM. PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning. J Mol Cell Cardiol 2002;34(6):661–668.

    CAS  PubMed  Google Scholar 

  9. Acitores A, Gonzalez N, Sancho V, Valverde I, Villanueva-Penacarrillo ML. Cell signalling of glucagon-like peptide-1 action in rat skeletal muscle. J Endocrinol 2004;180(3):389–398.

    CAS  PubMed  Google Scholar 

  10. Baines CP, Wang L, Cohen MV, Downey JM. Myocardial protection by insulin is dependent on phospatidylinositol 3-kinase but not protein kinase C or KATP channels in the isolated rabbit heart. Basic Res Cardiol 1999;94(3):188– 198.

    CAS  PubMed  Google Scholar 

  11. Jonassen AK, Sack MN, Mjos OD, Yellon DM. Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling. Circ Res 2001;89(12):1191– 1198.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Derek M. Yellon.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bose, A.K., Mocanu, M.M., Carr, R.D. et al. Glucagon Like Peptide-1 is Protective Against Myocardial Ischemia/Reperfusion Injury when Given Either as a Preconditioning Mimetic or at Reperfusion in an Isolated Rat Heart Model. Cardiovasc Drugs Ther 19, 9–11 (2005). https://doi.org/10.1007/s10557-005-6892-4

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10557-005-6892-4

Key Words

Navigation