Abstract
High dietary salt-caused hypertension is associated with increasing reactive oxygen species generation and reduced nitric oxide (NO) bioavailability. Transient receptor potential vanilloid type 1 (TRPV1), a specific receptor for capsaicin, is proposed to be involved in Dahl salt-sensitive hypertension, as determined in acute or short-term experiments. However, it remains unknown whether activation of TRPV1 by dietary capsaicin could prevent the vascular oxidative stress and hypertension induced by a high-salt diet. Here, we report that consumption of a high-salt diet blunted endothelium-dependent relaxation in mesenteric resistance arteries and elevated nocturnal blood pressure in mice. These effects were associated with increased superoxide anion generation and reduced NO levels in mesenteric vessels in mice on a high-salt diet. However, chronic administration of capsaicin reduced the high-salt diet-induced endothelial dysfunction and nocturnal hypertension in part by preventing the generation of superoxide anions and NO reduction of mesenteric arteries through vascular TRPV1 activation. Our findings provide new insights into the role of TRPV1 channels in the long-term regulation of blood pressure in response to high-salt intake. TRPV1 activation through chronic dietary capsaicin may represent a promising lifestyle intervention in populations with salt-sensitive hypertension.
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Acknowledgments
We thank Lijuan Wang (Chongqing Institute of Hypertension, China) for technical assistance. This research was supported by grants from the National Natural Science Foundation of China (30890042) and the National Basic Research Program of China (2011CB503902).
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The authors declare that no conflict of interest exists.
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Xinzhong Hao and Jing Chen contribute equally to this work.
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Hao, X., Chen, J., Luo, Z. et al. TRPV1 activation prevents high-salt diet-induced nocturnal hypertension in mice. Pflugers Arch - Eur J Physiol 461, 345–353 (2011). https://doi.org/10.1007/s00424-011-0921-x
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DOI: https://doi.org/10.1007/s00424-011-0921-x