Skip to main content

Advertisement

SpringerLink
Log in

Role of transforming growth factor-β in the progression of heart failure

  • Review
  • Published:
Cellular and Molecular Life Sciences CMLS Aims and scope Submit manuscript

Abstract.

Transforming growth factor (TGF-β) is a multifunctional peptide growth factor that has an important role in the regulation of cell growth, differentiation, and repair in a variety of tissues. In mammals, the cytokine has three isoforms, TGF-β1, TGF-β2, and TGF-β3. TGF- β1 is up-regulated by Ang II and induction of TGF-β1 causes cardiac fibrosis. The stimulus that triggers the expression of TGF-β1 may be repeated causing continual injury, which is associated with an increase in the activity of Ang II in heart tissue. The interplay between Ang II and TGF-β1 causes continued activation that may result in chronic hypertension and progressive myocardial fibrosis, leading to heart failure. The regulation of TGF-β1 secretion and action involves complex transcriptional events. Overproduction of TGF-β1 underlies tissue fibrosis. Understanding the actions and signaling transduction of TGF-β could lead to the development of therapeutic options that may be effective in inhibiting myocardial fibrosis triggered by TGF-β1 in heart failure.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, National University of Singapore, 10 Kent Ridge Crescent, Singapore, 119260, Singapore

    H. Lim & Y. Z. Zhu

  2. Department of Pharmacology, Faculty of Medicine, Methodist University of Indonesia, Medan, Indonesia

    H. Lim

  3. School of Pharmacy and Institute of Biomedical Sciences, Fudan University, Shanghai, 200032, P. R. China

    Y. Z. Zhu

Authors
  1. H. Lim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Y. Z. Zhu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Y. Z. Zhu.

Additional information

Received 26 February 2006; received after revision 10 June 2006; accepted 27 July 2006

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lim, H., Zhu, Y.Z. Role of transforming growth factor-β in the progression of heart failure. Cell. Mol. Life Sci. 63, 2584–2596 (2006). https://doi.org/10.1007/s00018-006-6085-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00018-006-6085-8

Keywords.

Search

Navigation