Comparative outcomes of the LAA Isolation and Preservation groups according to the lesion set
| Adverse events | Unadjusted | IPTW-adjusted | |||||||
| Biatrial ablation | |||||||||
| Early outcomes | Isolation (n=392) | Preservation (n=204) | OR | 95% CI | P value | OR | 95% CI | P value | |
| Event, no. of patients (%) | |||||||||
| Mortality (<30 days) | 4 (1.0) | 3 (1.5) | 0.69 | 0.15 to 3.12 | 0.630 | 2.26 | 0.74 to 6.85 | 0.151 | |
| Stroke | 1 (0.3) | 8 (3.9) | 0.06 | 0.01 to 0.51 | 0.009 | 0.09 | 0.02 to 0.16 | 0.004 | |
| Late outcomes | Event, n (no./100 PY) | Death, n | HR/SHR | 95% CI | P value | HR/SHR | 95% CI | P value | |
| Mortality | 62 (2.7) | 39 (3.1) | – | 0.85 | 0.57 to 1.26 | 0.414 | 0.82 | 0.49 to 1.37 | 0.447 |
| Stroke | 8 (0.4) | 8 (0.7) | 96 | 0.55 | 0.21 to 1.47 | 0.234 | 0.28 | 0.12 to 0.65 | 0.003 |
| AF recurrence | 102 (5.5) | 81 (9.5) | 68 | 0.64 | 0.48 to 0.86 | 0.003 | 0.77 | 0.61 to 0.94 | 0.029 |
| Left atrial ablation | |||||||||
| Early outcomes | Isolation (n=68) | Preservation (n=209) | OR | 95% CI | P value | OR | 95% CI | P value | |
| Event, no. of patients (%) | |||||||||
| Mortality (<30 days) | 1 (1.5) | 3 (1.4) | 1.03 | 0.11 to 10.12 | 0.983 | 0.63 | 0.17 to 2.42 | 0.503 | |
| Stroke | 3 (4.4) | 2 (1.0) | 4.78 | 0.78 to 29.21 | 0.091 | 2.60 | 0.74 to 9.17 | 0.138 | |
| Late outcomes | Event, n (no./100 PY) | Death, n | HR/SHR | 95% CI | P value | HR/SHR | 95% CI | P value | |
| Mortality | 62 (2.7) | 39 (3.1) | – | 0.85 | 0.57 to 1.26 | 0.414 | 0.82 | 0.49 to 1.37 | 0.447 |
| Stroke | – | 10 (0.9) | 28 | ||||||
| AF recurrence | 21 (10.1) | 47 (4.7) | 20 | 1.74 | 1.04 to 2.93 | 0.036 | 0.81 | 0.58 to 1.13 | 0.219 |
AF, atrial fibrillation; BA, biatrial; INR, international normalised ratio; IPTW, inverse-probability of treatment weighting; LA, left atrial; LAA, left atrial appendage; MV, mitral valve; PV, pulmonary vein; PY, patient-year; SA, surgical ablation; SHR, subdistribution HR.