Preoperative patient demographic and organ function data
| PaCO2-ValveDepl<60 mm Hg (n=149) | PaCO2-ValveDepl>60 mm Hg (n=52) | P value | PaCO2-%increase<50% (n=165) | PaCO2-%increase>50% (n=29) | P value | pH-ValveDepl> 7.2 (n=194) | pH- ValveDepl < 7.2 (n=7) | P value | |
| Sex (%) | |||||||||
| Female/male | 45.6/54.4 | 25.0/75.0 | 0.009 | 43.6/56.4 | 24.1/75.9 | 0.064 | 40.7/59.3 | 28.6/71.4 | 0.704 |
| Age (years) | |||||||||
| Mean±SD (range) | 79.7±8.5 (57.0–100.0) | 75.9±9.1 (49.0–92.0) | 0.007 | 79.2±8.6 (49.0–100.0) | 76.9±9.0 (60-91) | 0.183 | 78.9±8.8 (49.0–100.0) | 75.0±8.8 (66.0–91.0) | 0.253 |
| BMI (kg/m2) | |||||||||
| Mean±SD (range) | 28.6±5.0 (18.7–42.6) | 30.2±5.9 (22.1–48.0) | 0.094 | 29.1±5.2 (18.7–42.9) | 28.2±6.0 (22.0–48.0) | 0.205 | 29.0±5.3 (18.7–48.0) | 27.7±4.4 (23.0–36.3) | 0.515 |
| Weight (kg) | |||||||||
| Mean±SD (range) | 79.7±16.6 (43.5–136.1) | 87.8±19.9 (56.7–147.0) | 0.019 | 81.9±17.9 (43.5–147.4) | 80.4±17.0 (59.0–127.0) | 0.520 | 81.9±17.9 (43.5–147.4) | 80.3±16.7 (64.9–111.6) | 0.736 |
| COPD% | 17.5 | 17.3 | 1.000 | 17.6 | 13.8 | 0.791 | 17.0 | 28.6 | 0.351 |
| Asthma% | 15.4 | 9.6 | 0.359 | 14.6 | 3.5 | 0.135 | 13.9 | 14.3 | 1.000 |
| Smoking status% | |||||||||
| Never/previous/current | 40.3/55.7/4.0 | 30.8/63.5/5.8 | 0.439 | 39.4/55.8/4.8 | 31.0/65.5/3.5 | 0.691 | 37.6/58.2/4.1 | 42.9/42.9/14.3 | 0.284 |
| OSA% | 19.5 | 28.9 | 0.175 | 21.2 | 24.1 | 0.807 | 22.7 | 0.0 | 0.351 |
| Home O2% | 2.0 | 3.9 | 0.606 | 3.0 | 0.0 | 1.000 | 2.6 | 0.0 | 1.000 |
| GFR | |||||||||
| Mean (mL/min) ±SD (range) | 54.3±10.1 (6.0–60.0) | 56.0±10.0 (12.0–60.0) | 0.039 | 54.8±9.6 (12.0–60.0) | 56.9±8.5 (26.0–60.0) | 0.081 | 54.7±10.1 (6.0–60.0) | 56.9±8.3 (38.0–60.0) | 0.302 |
| LVEF | |||||||||
| Mean (%)±SD (range) | 59.7±13.2 (10.0–80.0) | 55.1±14.8 (15.0–80.0) | 0.054 | 58.7±13.7 (12.0–60.0) | 57.7±15.0 (15.0–75.0) | 0.798 | 58.4±13.9 (10.0–80.0) | 60.7±8.4 (55.0–75.0) | 0.875 |
| RVSP | |||||||||
| Mean (mm Hg)±SD (range) | 37.6±13.4 (18.0–90.0) | 37.7±11.1 (19.0–66.0) | 0.720 | 36.5±12.5 (18.0–90.0) | 39.9±11.0 (24.0–67.0) | 0.092 | 37.5±13.1 (18.0–90.0) | 41.0±5.4 (36.0–51.0) | 0.119 |
This compares PaCO2-sedation≤60 mm Hg and >60 mm Hg (201 total patients); PaCO2-%increase from baseline of ≤50% and >50% (194 total patients); and pH≤7.2 and >7.2 (201 total patients).
COPD, chronic obstructive pulmonary disease; GFR, glomerular filtration rate; LVEF, left ventricular ejection fraction; OSA, obstructive sleep apnoea; RVSP, right ventricular systolic pressure.