Scenario | Incremental costs | Incremental QALYs | ICER |
Base case | £641 | 0.17 | £3783 |
Blanking period implemented | £298 | 0.09 | £3219 |
Increased relative risk of AF recurrence relative to the number of previous ablations by 10% | £317 | 0.18 | £1722 |
Increased relative risk of AF resolution relative to the number of previous ablations by 10% | £899 | 0.16 | £5619 |
Decreased ablation success rate of 30% (proportionally) | £572 | 0.18 | £3252 |
Decreased incidence of stroke by 30% (proportionally) | £667 | 0.17 | £3977 |
EQ-5D form was replaced by AF Quality of Life Survey (AFEQT) form with additional utility decrement for higher European Heart Rhythm Association (EHRA) class | £614 | 0.08 | £7759 |
Changed health state specific stroke relative risk values to values sourced from published literature | £383 | 0.23 | £1690 |
Increased relative risk of developing heart failure for those in the permanent health state by 10% | £653 | 0.17 | £3830 |
Average selling price used for all procedure costs | £596 | 0.17 | £3565 |
2022/2023 cost used for ablation procedure cost | £790 | 0.17 | £4686 |
EQ-5D, EuroQoL 5 Dimensions; ICER, incremental cost-effectiveness ratio; QALY, quality adjusted life-year.