Details of study population and stratified by documented history of vasospastic angina (VSA)
| Participants, no. (%) | |||
| All | Without VSA | With VSA | |
| Overall | 5 764 770 | 5 761 309 (99.94) | 3461 (0.06) |
| Sex | |||
| Male | 2 954 982 (51.26) | 2 953 757 (51.27) | 1225 (35.39) |
| Female | 2 809 788 (48.74) | 2 807 552 (48.73) | 2236 (64.61) |
| Year of birth, median (IQR) [range] | 1974 (1955–1994) [1932–2018] | 1974 (1955–1994) [1932–2018] | 1946 (1941–1954) [1932–1990] |
| Age at end of follow-up, median (IQR) [range] | 43 (24–62) [0–86] | 43 (24–62) [0–86] | 59 (53–66) [21–85] |
| Age at Prinzmetal onset, median (IQR) [range] | NA | NA | 59 (53–66) [21–85] |
| Education | |||
| Unknown or 1–9 years | 692 193 (12.01) | 691 197 (12.00) | 996 (28.78) |
| 10–11 years | 2 422 567 (42.02) | 2 420 999 (42.02) | 1568 (45.30) |
| >11 years | 2 650 010 (45.97) | 2 649 113 (45.98) | 879 (25.92) |
| Source | |||
| Hospital discharge register | NA | NA | 2218 (64.09) |
| Outpatient register | NA | NA | 1243 (35.91) |
| Spouse | |||
| Husband | NA | NA | 1199 (39.38) |
| Wife | NA | NA | 1846 (60.62) |
| Comorbidity | |||
| Hypertension | 640 698 (11.11) | 638 405 (11.08) | 2293 (66.25) |
| Hyperlipidaemia | 222 912 (3.87) | 221 306 (3.84) | 1606 (46.40) |
| COPD | 108 472 (1.88) | 108 092 (1.88) | 380 (10.98) |
| Obesity | 163 979 (2.84) | 163 688 (2.84) | 291 (8.41) |
| Diabetes mellitus | 254 726 (4.42) | 253 996 (4.41) | 730 (21.09) |
| Myocardial infarction | 117 747 (2.04) | 116 661 (2.02) | 1086 (31.38) |
| Raynaud’s phenomenon | 4216 (0.07) | 4197 (0.07) | 19 (0.55) |
| Migraine | 111 908 (1.94) | 111 731 (1.94) | 177 (5.11) |
| Cluster headache (Horton syndrome) | 4765 (0.08) | 4759 (0.08) | 6 (0.17) |
| Myocarditis | 8420 (0.15) | 8390 (0.15) | 30 (0.87) |
| Malignancy | 520 725 (9.03) | 519 826 (9.02) | 899 (25.98) |
| Oesophagal disease | 185 985 (3.23) | 185 427 (3.22) | 558 (16.12) |
| Alcohol abuse | 178 405 (3.09) | 178 222 (3.09) | 183 (5.29) |
| Cocaine abuse | 2294 (0.04) | 2292 (0.04) | 2 (0.06) |
| Tobacco use | 93 406 (1.62) | 93 087 (1.62) | 319 (9.22) |
COPD, chronic obstructive pulmonary disease.