Risk of vasospastic angina (VSA) in siblings with and without an affected sibling
| Variable | Person-year no. | Cases, no./ persons at risk, no. | Incidence rate, cases/1000 person-years | Incidence rate ratio (95% CI) | HR (95% CI) | ||
| Model 1 | Model 2 | Model 3 | |||||
| Sibling not affected | 187 909 313 | 7801/10 136 643 | 0.04 (0.04–0.04) | 1 (Reference) | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Sibling affected | 152 474 | 48/7849 | 0.31 (0.24–0.42) | 7.58 (5.71 to 10.07) | 7.64 (5.17 to 11.31) | 3.39 (2.28 to 5.03) | 2.56 (1.73 to 3.79) |
Model 1 unadjusted. Model 2 adjusted for birth year, sex and educational attainment. Model 3 additionally adjusted for hypertension, hyperlipidaemia, COPD, obesity, diabetes mellitus, myocardial infarction, Raynaud’s phenomenon, migraine, cluster headache Horton syndrome, myocarditis, malignancy, oesophageal disease, alcohol abuse, cocaine abuse, tobacco use.
All calculations are based on double entry and 95% CI are calculated using robust SEs.
COPD, chronic obstructive pulmonary disease.