(A) Characteristics of patients without previous myocardial infarction and/or coronary revascularisation according to cardiac events and (B) characteristics of patients with previous myocardial infarction and/or coronary revascularisation according to cardiac events
| (A) | |||
| Variables | Without CE | With CE | P value |
| n=2880 | n=80 | ||
| Age (years) | 64.1±11.2 | 70.3±9.5 | <0.001 |
| Age>66 (%) | 1396 (48.5) | 63 (78.8) | <0.001 |
| Male (%) | 1669 (58) | 51 (63.8) | 0.3 |
| Weight (Kg) | 74.4±13 | 72.8±11.8 | 0.306 |
| Height (cm) | 164.3±11.7 | 162.8±8.6 | 0.283 |
| Body mass index* | 28.2±4 | 27.5±4 | 0.687 |
| Obesity (%)† | 603 (20.9) | 18 (22.5) | 0.735 |
| Diabetes (%) | 491 (17) | 30 (37.5) | <0.001 |
| Hypertension (%) | 1699 (59) | 51 (63.8) | 0.393 |
| Hyperlipidaemia (%) | 1396 (48.5) | 40 (50) | 0.787 |
| Smoker (%) | 1144 (39.7) | 35 (43.8) | 0.468 |
| Angina prior gated SPECT | 301 (10.5) | 14 (17.5) | 0.044 |
| Rest heart rate (bpm) | 72.4±14 | 72.1±15 | 0.89 |
| Rest systolic blood pressure (mm Hg) | 129.7±34 | 139.4±36.2 | 0.012 |
| Medical treatment (%) | |||
| Beta-blockers (%) | 770 (26.7) | 20 (25) | 0.729 |
| Nitrates (%) | 683 (23.7) | 34 (42.5) | <0.001 |
| Calcium channel blockers (%) | 504 (17.5) | 24 (30) | 0.004 |
| Stress test | |||
| METs | 6.1±3.1 | 5.1±1.9 | <0.001 |
| METs≤6.08 (%) | 1483 (51.5) | 62 (77.5) | <0.001 |
| Exercise test angina | 379 (13.2) | 11 (13.8) | 0.878 |
| ↓ ST mm | 0.3±0.3 | 0.6±0.4 | <0.001 |
| ↓ ST mm≥1 (%) | 463 (16.1) | 29 (36.2) | <0.001 |
| SPECT stress rest | |||
| Summed rest score | 5.8±1.7 | 7.1±2.6 | <0.001 |
| Summed rest score>6 (%) | 512 (17.8) | 39 (48.8) | <0.001 |
| Summed stress score | 6.6±2.4 | 9.1±3.5 | <0.001 |
| Summed stress score>6 (%) | 1088 (37.8) | 60 (75) | <0.001 |
| Summed difference score | 0.9±1.5 | 2.2±2.5 | <0.001 |
| Summed difference score≥2 (%) | 332 (11.5) | 24 (30) | <0.001 |
| Gated | |||
| Left ventricular ejection fraction (%) | 61.6±15.4 | 54.4±15.5 | <0.001 |
| Left ventricular ejection fraction≤57% (%) | 973 (33.8) | 50 (62.5) | <0.001 |
| End-systolic volume (mL) | 37.4±34.3 | 51.5±42 | 0.02 |
| End-systolic volume>36 mL (%) | 1005 (34.9) | 48 (60) | <0.001 |
| End-diastolic volume (mL) | 85.1±41.9 | 99.4±48 | 0.042 |
| End-diastolic volume>77 mL (%) | 1387 (48.2) | 51 (63.8) | 0.006 |
| (B) | |||
| Variable | Without CE | With CE | P value |
| n=2123 | n=132 | ||
| Age (years) | 62.9±11 | 68.9±9.4 | <0.001 |
| Age>67.8 (%) | 796 (37.5) | 80 (60.6) | <0.001 |
| Male (%) | 1728 (81.4) | 118 (89.4) | 0.021 |
| Weight (Kg) | 75.2±13 | 73.7±14.3 | 0.199 |
| Height (cm) | 164.6±10 | 165±7.9 | 0.64 |
| Body mass index* | 28.5±17.7 | 27±4.6 | 0.363 |
| Obesity (%)† | 492 (23.2) | 21 (15.9) | 0.053 |
| Diabetes (%) | 424 (20) | 46 (34.8) | <0.001 |
| Hypertension (%) | 1156 (54.5) | 80 (60.6) | 0.168 |
| Hyperlipidaemia (%) | 1331 (62.7) | 78 (59.1) | 0.407 |
| Smoker (%) | 1246 (58.7) | 87 (65.9) | 0.102 |
| Angina prior gated SPECT | 265 (12.5) | 15 (11.4) | 0.705 |
| Rest heart rate (bpm) | 66.7±13 | 74.6±20 | 0.22 |
| Rest systolic blood pressure (mm Hg) | 125.8±28 | 125.9±29 | 0.943 |
| Medical treatment (%) | |||
| Beta-blockers (%) | 1287 (60.6) | 73 (55.3) | 0.226 |
| Nitrates (%) | 742 (35) | 69 (52.3) | <0.001 |
| Calcium channel blockers (%) | 384 (18.1) | 25 (18.9) | 0.805 |
| Stress test | |||
| METs | 6.5±2.6 | 5.2±1.8 | <0.001 |
| METs≤5.6 (%) | 731 (34.4) | 84 (63.6) | <0.001 |
| Angina during stress test | 316 (14.9) | 20 (15.2) | 0.933 |
| ↓ ST mm | 0.3±0.7 | 0.55±0.4 | 0.009 |
| ↓ ST mm≥1 (%) | 431 (20.3) | 38 (28.8) | 0.02 |
| SPECT stress-rest | |||
| Summed rest score | 8.1±3.1 | 9.8±3.4 | <0.001 |
| Summed rest score>8 (%) | 764 (36) | 78 (59.1) | <0.001 |
| Summed stress score | 9.3±3.4 | 11.3±3.4 | <0.001 |
| Summed stress score>8 (%) | 1105 (52) | 101 (76.5) | <0.001 |
| Summed difference score | 1.25±1.2 | 1.6±1 | 0.045 |
| Summed difference score≥2 (%) | 296 (13.9) | 23 (17.4) | 0.265 |
| Gated | |||
| Left ventricular ejection fraction (%) | 55.1±14 | 44.7±14.6 | <0.001 |
| Left ventricular ejection fraction≤48 (%) | 623 (29.3) | 79 (59.8) | <0.001 |
| End-systolic volume (mL) | 50.7±40 | 80.3±40 | <0.001 |
| End-systolic volume>46 mL (%) | 830 (39.1) | 90 (68.2) | <0.001 |
| End-diastolic volume (mL) | 101.9±49 | 133.1±60.8 | <0.001 |
| End-diastolic volume>98 mL (%) | 895 (42.2) | 91 (68.9) | < 0.001 |
*Quetelet Index: weight (kg)/height (m2).
†Obesity was defined as a body mass index ≥ 30 kg/m2.
CE, cardiac events; MET, metabolic equivalent; SPECT, single photon emission CT.