Clinical and echocardiographic characteristics associated with more severe tricuspid regurgitation in patients with RHD
| At baseline | Unadjusted | Multivariable adjustment for age, female sex, atrial fibrillation, SPAP, LVEF and RA area | Multivariable adjustment for age, female sex, atrial fibrillation, SPAP, LVEF, RA area and RV dysfunction* | |||
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |
| Age, years | 1.062 (1.041 to 1.084) | <0.001 | 1.049 (1.017 to 1.081) | 0.002 | 1.061 (1.029 to 1.094) | <0.001 |
| Female sex | 1.069 (0.556 to 2.055) | 0.841 | 1.706 (0.701 to 4.151) | 0.239 | 1.986 (0.795 to 4.964) | 0.142 |
| Atrial fibrillation | 4.755 (2.925 to 7.728) | <0.001 | 1.650 (0.717 to 3.797) | 0.239 | 1.042 (0.425 to 2.552) | 0.929 |
| SPAP (mm Hg) | 1.029 (1.017 to 1.042) | <0.001 | 1.051 (1.030 to 1.071) | <0.001 | 1.041 (1.021 to 1.061) | <0.001 |
| LVEF (%) | 0.943 (0.918 to 0.969) | <0.001 | 0.995 (0.995 to 1.0376) | 0.796 | 1.008 (0.965 to 1.053) | 0.728 |
| RA area (cm2) | 1.238 (1.173 to 1.308) | <0.001 | 1.196 (1.117 to 1.281) | <0.001 | 1.188 (1.115 to 1.265) | <0.001 |
| RV dysfunction* | 7.793 (4.683 to 12.967) | <0.001 | 2.927 (1.401 to 6.115) | 0.004 | ||
Model without RV dysfunction: C-statistic of 0.878 (95% CI 0.836 to 0.920).
Model with RV dysfunction: C-statistic of 0.888 (95% CI 0.844 to 0.932).
*RV function was assessed using a combination of parameters and categorised in normal or impaired function.
LVEF, left ventricular ejection fraction; RA, right atrium; RHD, rheumatic heart disease; RV, right ventricular; SPAP, systolic pulmonary artery pressure.