Cases (n=35.195) | Controls (n=351.950) | Crude HR (95% CI) | Adjusted HR (95% CI) | |
Present | 18.965 | 104.524 | ||
Neither of the two diagnoses | 18.604 (98.10%) | 103.424 (98.95%) | Reference | Reference |
Long-term stress | 165 (0.87%) | 519 (0.50%) | 1.77 (1.48 to 2.11) | 1.13 (0.94 to 1.36) |
Anxiety | 178 (0.94 %) | 533 (0.51%) | 1.86 (1.57 to 2.20) | 1.36 (1.13 to 1.63) |
Both diagnoses | 18 (0.09%) | 48 (0.05%) | 2.09 (1.21 to 3.58) | 1.28 (0.72 to 2.27) |
Absent | 16.230 | 247.426 | ||
Neither of the two diagnoses | 15.927 (98.13%) | 245.513 (99.23%) | Reference | Reference |
Long-term stress | 159 (0.98%) | 1.058 (0.43%) | 2.32 (1.96 to 2.74) | 1.59 (1.34 to 1.89) |
Anxiety | 121 (0.75 %) | 765 (0.31%) | 2.44 (2.01 to 2.96) | 1.64 (1.35 to 2.00) |
Both diagnoses | 23 (0.14%) | 90 (0.04%) | 3.94 (2.49 to 6.23) | 2.33 (1.46 to 3.73) |
Numbers in table are number (%) unless indicated otherwise. HR adjusted for presence of cardiovascular disease, depression and the use of QT-prolonging drugs. Furthermore, by conducting stratified analyses according cardiovascular disease, the original matching on age and sex was lost. Therefore, HRs were additionally adjusted for age and sex.
P value interaction: long-term stress=0.8973, anxiety=0.5988, both diagnoses=0.1667.