Results of multivariable Cox proportional hazard model testing the association between haematological parameters and clinical outcomes
| Unadjusted | Multivariable-adjusted model* | |||
| HR (95% CI) | P value | HR (95% CI) | P value | |
| All-cause mortality | ||||
| Preoperative anaemia | 1.8 (1.3 to 2.5) | <0.001 | 1.6 (1.1 to 2.0) | 0.01 |
| Postoperative anaemia | 1.9 (1.3 to 3.0) | 0.002 | 1.5 (1.04 to 2.5) | 0.048 |
| Preoperative haemoglobin† | 1.1 (1.08 to 1.2) | <0.001 | 1.1 (1.02 to 1.2) | 0.01 |
| Postoperative haemoglobin | 1.2 (1.1 to 1.3) | <0.001 | 1.2 (1.1 to 1.3) | 0.002 |
| Preoperative thrombocytopaenia | 1.7 (1.2 to 2.3) | 0.001 | 1.4 (1.01 to 2.0) | 0.03 |
| Postoperative thrombocytopaenia | 1.3 (0.9 to 1.7) | 0.12 | 1.1 (0.8 to 1.5) | 0.56 |
| Preoperative NLR>3.2 | 1.7 (1.2 to 2.3) | 0.001 | 1.4 (1.01 to 2.0) | 0.03 |
| Postoperative NLR>5 | 1.8 (1.2 to 2.6) | 0.002 | 1.6 (1.1 to 2.4) | 0.01 |
| Preoperative PLR>140 | 1.2 (0.9 to 1.6) | 0.2 | 1.1 (0.8 to 1.5) | 0.5 |
| Postoperative PLR>137 | 1.7 (1.2 to 2.6) | 0.002 | 1.6 (1.1 to 2.3) | 0.01 |
| MACCE | ||||
| Preoperative anaemia | 2.1 (1.4 to 2.9) | <0.001 | 1.9 (1.3 to 2.8) | 0.002 |
| Postoperative anaemia | 3.0 (1.7 to 5.4) | <0.001 | 2.6 (1.4 to 4.9) | 0.003 |
| Preoperative haemoglobin | 1.2 (1.1 to 1.3) | <0.001 | 1.1 (1.05 to 1.2) | 0.002 |
| Postoperative haemoglobin | 1.3 (1.1 to 1.4) | <0.001 | 1.2 (1.1 to 1.3) | 0.003 |
| Preoperative thrombocytopaenia | 0.9 (0.6 to 1.6) | 0.99 | 1.04 (0.6 to 1.7) | 0.85 |
| Postoperative thrombocytopaenia | 0.7 (0.5 to 1.0) | 0.08 | 0.7 (0.4 to 1.0) | 0.07 |
| Preoperative NLR>3.2 | 1.8 (1.2 to 2.6) | 0.002 | 1.6 (1.1 to 2.4) | 0.01 |
| Postoperative NLR>5 | 1.7 (1.2 to 2.6) | 0.005 | 1.7 (1.1 to 2.6) | 0.01 |
| Preoperative PLR>140 | 1.7 (1.1 to 2.4) | 0.006 | 1.6 (1.1 to 2.4) | 0.01 |
| Postoperative PLR>137 | 2.2 (1.5 to 3.3) | <0.001 | 2.1 (1.3 to 3.2) | 0.001 |
Anaemia is defined as haemoglobin <12 g/dL in females and <13 g/dL in males. Thrombocytopaenia is defined as platelet count <150 x 109/L.
*Adjusted for age, gender, body mass index, comorbidities (hypertension, diabetes, coronary artery disease, congestive heart failure, atrial fibrillation), left ventricular ejection fraction, New York Heart Association class, serum creatinine and urgent status.
†Per 1 unit decrease.
MACCE, major adverse cardiovascular and cerebrovascular events ; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio.