Table 2

Examples of clinical studies utilising endothelial function for prognosis

Clinical studyStudy subjectsAuthor, yearNEndo measurePredictive?
Cardiovascular health studyOlder adults, asymptomaticYeboah, J, 2007
Circulation		2792FMD+/-
Predictive, but adds little to prognostic accuracy of traditional risk factors
Multiethnic study of atherosclerosisAvg age 61, white, Chinese, Black, Hispanic, asymptomaticYeboah J,
2009
Circulation		3026FMD+
Firefighters and their endotheliumHealthy firefightersAnderson TJ, 2011
Circulation		1574FMD–
Patients with chest painPatients with CAD and without CAD on coronary angiogramHalcox, J PJ, 2002
Circulation		308Intracoronary AcH+ (for patients with CAD and without)
Patients with vascular diseasePatients undergoing vascular surgeryGocke, N, 2003
JACC		199Brachial FMD+
Symptomatic outpatients with chest painPatients with low-risk findings on stress study or absence of obstructive lesions on angiogramRubinshtein R, 2010
European Heart Journal		329Endo pat+
Patients with stable CADPatients with CAD proven angiographicallySinning, J-M, 2010
European Heart Journal		200CD31+/annexin V+microparticles+

  • AcH, acetylcholine; CAD, coronary artery disease; FMD, flow-mediated dilation.