Table 3

Predictors of worsening renal function (≥20% decline in eGFR) over time

CharacteristicsOR (95% CI)P value
CKD stages
 eGFR ≥90Reference
 eGFR 60–891.13 (0.79 to 1.61)0.51
 eGFR 30–591.05 (0.71 to 1.55)0.82
 eGFR 15–291.09 (0.61 to 1.97)0.77
 eGFR <15/dialysis1.25 (0.39 to 3.97)0.71
Age (/10 years)1.49 (1.35 to 1.65)<0.001
Sex, female1.29 (1.10 to 1.52)0.002
Hypertension1.17 (0.98 to 1.39)0.09
Diabetes mellitus1.55 (1.27 to 1.90)<0.001
Prior stroke/TIA/systemic embolism0.75 (0.60 to 0.95)0.02
Prior MI1.01 (0.73 to 1.40)0.93
Prior PCI or CABG1.13 (0.85 to 1.49)0.41
Heart failure1.91 (1.53 to 2.39)<0.001
Peripheral vascular disease1.31 (0.93 to 1.83)0.12
COPD1.34 (0.99 to 1.81)0.06
Cancer (within 3 years)0.81 (0.57 to 1.16)0.26
Prior major bleeding1.21 (0.89 to 1.63)0.23
  • CABG, coronary artery bypass grafting; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; eGFR, estimated glomerular filtration rate; MI, myocardial infarction; PCI, percutaneous coronary intervention; TIA, transient ischaemic attack.