Association between female sex and the prevalence of brain lesions
| Prevalence | Univariable | Age adjusted model | Multivariable adjusted model |
| All patients (n=1743) OR (95% CI) | All patients (n=1743) OR (95% CI) | All patients (n=1727) OR (95% CI) | |
| Large noncortical and cortical infarcts | 0.81 (0.62 to 1.04) p=0.11 | 0.73 (0.56 to 0.95) p=0.02 | 0.86 (0.65 to 1.14) p=0.28 |
| Small noncortical infarcts | 0.90 (0.70 to 1.17) p=0.44 | 0.78 (0.59 to 1.01) p=0.06 | 0.82 (0.62 to 1.09) p=0.18 |
| Ischaemic lesions (LNCCI and SNCI) | 0.87 (0.70 to 1.08) p=0.21 | 0.75 (0.60 to 0.94) p=0.01 | 0.86 (0.67 to 1.09) p=0.22 |
| Microbleeds | 0.91 (0.70 to 1.17) p=0.47 | 0.81 (0.62 to 1.06) p=0.13 | 0.91 (0.68 to 1.21) p=0.52 |
| White matter hyperintensities, Fazekas≥2 | 1.35 (1.09 to 1.67) p=0.006 | 1.11 (0.88 to 1.40) p=0.37 | 1.15 (0.90 to 1.48) p=0.27 |
Data are presented as OR and 95% CI; predictor of interest: female sex; multivariable adjusted model was adjusted for age, body mass index, smoking status, AF type (paroxysmal vs non-paroxysmal), systolic blood pressure, hypertension, diabetes mellitus, heart failure, coronary heart disease, sleep apnoea, statin therapy, antihypertensive medication, oral anticoagulation, antiplatelet therapy. Missing values: microbleeds count (n=55); white matter hyperintensities (n=1); covariates (n=16).
AF, atrial fibrillation; LNCCI, large noncortical and cortical infarcts (including acute lesions); SNCI, small noncortical infarcts (including acute lesions).