Characteristics* | Continued MRA (n=275) | Discontinued MRA (n=297) | P value |
Female sex, n (%) | 71 (26) | 107 (36) | 0.008 |
Age, years | 72 ± (11) | 77 ± (12) | <0.001 |
LVEF, % | 36 ± (8) | 37 ± (10) | 0.054 |
Medical history, n (%) | |||
Diabetes | 17 (8) | 12 (5) | 0.271 |
Hypertension | 181 (66) | 216 (73) | 0.063 |
Coronary artery disease† | 133 (49) | 151 (52) | 0.563 |
CRT/CRT-D/ICD | 62 (23) | 71 (24) | 0.700 |
Open heart surgery‡ | 61 (22) | 81 (28) | 0.146 |
Atrial fibrillation | 121 (44) | 161 (54) | 0.015 |
Physical examination | |||
Heart rate, bpm | 74 ± (16) | 75 ± (16) | 0.279 |
Systolic BP, mm Hg | 123 ± (19) | 127 ± (20) | 0.036 |
Diastolic BP, mm Hg | 73 ± (12) | 73 ± (12) | 0.635 |
BMI, n (%) | 28 ± (6) | 27 ± (5) | 0.082 |
NT-proBNP (ng/L) (median (IQR)) | 979 (432–2481) | 1547 (573–3531) | 0.002 |
S-haemoglobin, mmol/L | 134 ± (17) | 132 ± (17) | 0.120 |
S-sodium, mmol/L | 139 ± (3) | 139 ± (3) | 0.458 |
S-potassium, mmol/L | 4.4 ± (0.5) | 4.3 ± (0.5) | 0.242 |
eGFR, ml/min/1.73 m2 | 59 ± (17) | 50 ± (19) | <0.001 |
Medications, n (%) | |||
ACEI/ARB/ARNI | 257 (94) | 267 (90) | 0.125 |
Beta-blocker | 255 (93) | 268 (90) | 0.287 |
Loop diuretic | 174 (63) | 202 (68) | 0.233 |
Thiazide diuretic | 7 (3) | 8 (3) | 0.912 |
*Values are means and SD, no. (%) or median (IQR) when appropriate. P values are from the χ2, Student’s t-test, Mann-Whitney U test or Fisher’s exact test as appropriate.
†Coronary artery disease defined as either previous myocardial infarction or documented stenosis of ≥50%.
‡Open heart surgery includes coronary artery bypass graft/heart valve surgery/other.
ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; ARNI, angiotensin receptor neprilysin inhibitor; BMI, body mass index; BP, blood pressure; CRT, Cardiac Resynchronisation Therapy; CRT-D, CRT with defibrillator; eGFR, estimated glomerular filtration rate; ICD, implantable cardioverter-defibrillator; LVEF, left ventricular ejection fraction; MRA, mineralocorticoid receptor antagonist; NT-proBNP, N-terminal pro-B-type natriuretic peptide.