Hazard rates of HES-recorded bleeding, CPRD-recorded bleeding and total bleeding (HES and CPRD) by antiplatelet regimen in participants with ACS and STEMI. Rates were calculated taking into account time to first bleed only
| ACS | STEMI | ||||||||||||||
| AC | AT | AC | AP | AT | |||||||||||
| Total bleeds | Person years | Rate per 1000 person years at risk (95% CI) | Total bleeds | Person years | Rate per 1000 person years at risk (95% CI) | Total bleeds | Person years | Rate per 1000 person years at risk (95% CI) | Total bleeds | Person years | Rate per 1000 person years at risk (95% CI) | Total bleeds | Person years | Rate per 1000 person years at risk (95% CI) | |
| HES-recorded bleeding | 63 | 2731 | 23.1 (18.0 to 29.5) | 54 | 1888 | 28.6 (21.9 to 37.3) | 22 | 1008 | 21.8 (14.4 to 33.2) | 9 | 400 | 22.5 (11.7 to 43.2) | 39 | 1133 | 34.4 (25.1 to 47.1) |
| CPRD-recorded bleeding | 161 | 2671 | 60.3 (51.7 to 70.3) | 170 | 1807 | 94.1 (81.0 to 109.4) | 62 | 982 | 63.2 (49.2 to 81.0) | 39 | 381 | 102.3 (74.8 to 140.1) | 106 | 1089 | 97.4 (80.5 to 117.8) |
| CPRD-recorded and HES-recorded bleeding | 209 | 2344 | 89.2 (77.9 to 102.1) | 206 | 1543 | 133.5 (116.5 to 153.1) | 80 | 862 | 92.8 (74.6 to 115.6) | 46 | 334 | 137.8 (103.2 to 183.9) | 133 | 928 | 143.4 (121.0 to 170.0) |
AC, aspirin and clopidogrel; ACS, acute coronary syndrome; AP, aspirin and prasugrel; AT, aspirin and ticagrelor; CPRD, Clinical Practice Research Datalink; HES, Hospital Episode Statistics; STEMI, ST-elevation myocardial infarction.