Echocardiography findings and cytokine levels in patients undergoing aortic valve replacement
| Variables Median (max - min) | Total | Biological prosthesis | Mechanical prosthesis | P value |
| n=80 | n=53 | n=27 | ||
| Echocardiographic findings | ||||
| LVEF (%) | 60(24-68) | 60(24-68) | 60(30-68) | 0.67* |
| LV mass (gr/m2/BSA) | 90.5 ± 24.9† | 87.7 ± 25.2† | 95.9 ± 23.8† | 0.16‡ |
| Peak Velocity (m/s) | 2.5 ± 0.71† | 2.5 ± 0.68† | 2.58 ± 0.79† | 0.63‡ |
| Mean Gradient (mm Hg) | 16 (17-72) | 16 (17-72) | 16 (7-49) | 0.95 |
| EOA (cm2) | 1.6 (0.4–2.6) | 1.6 (0.4–2.2) | 1.6 (0.53–2.6) | 0.44 |
| TAPSE (mm) | 18 (12-24) | 18 (12-24) | 19 (14-22) | 0.15 |
| PSAP (mm Hg) | 32.5 (18–67) | 34(21-67) | 31(18-52) | 0.50 |
| Cytokine levels | ||||
| Endothelin 1 (pg/mL) | 0.6 (0.08–13.64) | 0.60 (0.08–13.64) | 0.60 (0.08–11.13) | 0.60 |
| IL-1ß (pg/cm3) | 3 (3–1282.8) | 3 (3–649.9 | 3 (3–1282.8) | 0.16 |
| IL-4 (pg/mL) | 30 (30–258.4) | 30(30-30) | 30 (30–258.4) | 0.01 |
| IL-6 (pg/mL) | 10 (10–56.5) | 10(10-10) | 10 (10–56.5) | 0.16 |
| Osteopontin (pg/mL) | 3618±1293† | 3413±1362† | 4023±1053† | 0.04‡ |
| Osteoprogesterin (pg/mL) | 1910.3±822.8† | 2071±862.9† | 1594.7±641.7† | 0.01‡ |
| RANK (pg/mL) | 50 (50–1990.6) | 50 (50–1288.9) | 50 (50–1990.6) | 0.19 |
| RANK-L (pg/mL) | 50 (50–50) | 50 (50–50) | 50 (50–50) | NS |
| TNFα (pg/mL) | 15 (11.3–527.1) | 15 (11.3–388.7) | 15 (15–527.1) | 0.47 |
*Mann-Whitney U test.
†Mean(±SD).
‡Student’s t-test.
BSA, body surface area; EOA, effective orifice area; IL, interleukin; LV, left ventricle; LVEF, left ventricular ejection fraction; NS, not significant; PSAP, pulmonary systolic artery pressure; RANK, receptor activator of nuclear-factor kappa B; RANK-L, receptor activator of nuclear-factor kappa B ligand; TAPSE, tricuspid annular plane systolic excursion; TAPSE, Tricuspid annular plane systolic excursion; TNFα, tumour necrosis factor alpha.