Patientcharacteristics and comparison of 2 cohorts of patients—HFrEF/HFmrEF versus those with HFpEF
| Patient characteristics | Total cohort (n=334) | HFrEF/ HFmrEF (n=184) | HFpEF (n=150) | P value (HFrEF vs HFpEF) |
| Age | 72.5±11 years | 71±9 years | 74.5±11 | 0.001 |
| Male:female | 57%:43% | 60%:40% | 47%:53% | 0.02 |
| Ischaemic heart disease | 124/334 (37%) | 94/184 (51%) | 30/150 (20%) | <0.001 |
| Hypertension | 164/334 (49%) | 78/184 (42%) | 86/150 (57%) | 0.007 |
| Diabetes mellitus | 137/334 (41%) | 72/184 (39%) | 65/150 (43%) | 0.43 |
| Atrial fibrillation | 127/334 (38%) | 67/184 (36%) | 60/150 (40%) | 0.50 |
| Valvular heart disease | 60/334 (18%) | 29/184 | 31/150 | 0.24 |
| COPD/asthma/interstitial lung disease | 103/334 (31%) | 53/184 (29%) | 50/150 (33%) | 0.37 |
| CKD | 177/334 (53%) | 81/184 (44%) | 96/150 (64%) | <0.001 |
| Cerebrovascular disease (CVA or previous TIA) | 43/334 (13%) | 22/184 (12%) | 21/150 (13%) | 0.6 |
| Cancer | 23/334 (7%) | 15/184 (8%) | 8/150 (5%) | 0.3 |
| Dementia | 27/334 (8%) | 16/184 (8%) | 11/150 (7%) | 0.5 |
| Charlson Comorbidity Index | 7.6±2.1 | 7.4±2 | 7.9±2.2 | 0.03 |
| Rockwood Frailty Score | 5.5±1.6 | 5.4 1.5 | 5.7±1.7 | 0.06 |
CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; CVA, cerebrovascular accident; HFmrEF, heart failure with mildly reduced ejection fraction; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; TIA, transient ischaemic attack.