Adjusted/unadjusted | Outcome | Predictor | # Case–control pairs | AUC (95% CI) | AUC P value* | Optimal cut-off point† | Sensitivity | Specificity |
Unadjusted | c-AKI | IGFBP7 (ng/mL) | 17 | 0.81 (0.66 to 0.96) | <0.001 | 102 ng/mL | 0.82 | 0.76 |
NT-pro-BNP (pg/mL) | 18 | 0.51 (0.31 to 0.71) | 0.46 | 1295 pg/mL | 0.83 | 0.33 | ||
PAPi | 11 | 0.61 (0.36 to 0.87) | 0.19 | 1.08 | 0.64 | 0.64 | ||
AKI | IGFBP7 (ng/mL) | 48 | 0.74 (0.64 to 0.84) | <0.001 | 102 ng/mL | 0.71 | 0.71 | |
NT-pro-BNP (pg/mL) | 49 | 0.55 (0.44 to 0.67) | 0.21 | 459 pg/mL | 0.49 | 0.69 | ||
PAPi | 38 | 0.57 (0.44 to 0.70) | 0.14 | 1.84 | 0.87 | 0.32 | ||
RVF | IGFBP7 (ng/mL) | 50 | 0.65 (0.54 to 0.76) | 0.004 | 89.5 ng/mL | 0.64 | 0.64 | |
NT-pro-BNP (pg/mL) | 51 | 0.60 (0.49 to 0.71) | 0.04 | 1313 pg/mL | 0.75 | 0.51 | ||
PAPi | 32 | 0.51 (0.36 to 0.65) | 0.44 | 0.86 | 0.88 | 0.28 | ||
Adjusted | c-AKI | IGFBP7 (ng/mL) | 17 | 0.90 (0.81 to 1.00) | <0.001 | -- | 0.82 | 0.82 |
NT-pro-BNP (pg/mL) | 18 | 0.87 (0.76 to 0.99) | <0.001 | -- | 0.72 | 0.94 | ||
PAPi | 11 | 0.77 (0.56 to 0.97) | 0.004 | -- | 0.73 | 0.73 | ||
AKI | IGFBP7 (ng/mL) | 47 | 0.79 (0.67 to 0.88) | <0.001 | -- | 0.68 | 0.79 | |
NT-pro-BNP (pg/mL) | 48 | 0.78 (0.68 to 0.87) | <0.001 | -- | 0.73 | 0.77 | ||
PAPi | 38 | 0.68 (0.56 to 0.81) | 0.003 | -- | 0.34 | 0.97 | ||
RVF | IGFBP7 (ng/mL) | 49 | 0.69 (0.58 to 0.80) | <0.001 | -- | 0.67 | 0.69 | |
NT-pro-BNP (pg/mL) | 50 | 0.74 (0.64 to 0.83) | <0.001 | -- | 0.64 | 0.76 | ||
PAPi | 32 | 0.69 (0.56 to 0.82) | 0.002 | -- | 0.34 | 0.97 |
*P values were derived from the sampling distribution of the AUC statistic, assuming normality and represent the proportion of the distribution lying at or below 0.5.
†Optimal cut-off points determined by maximising Youden’s index. Any ties were broken by minimising the distance to the upper left corner.
AKI, acute kidney injury; c-AKI, congestive AKI; NT-pro-BNP, N-terminal pro hormone B-type natriuretic peptide; PAPi, Pulmonary Artery Pulsatility Index; RVF, right ventricular failure.