Table 3

Area under the receiver-operating curve (AUC), optimal cut-off points and associated sensitivity and specificity for all adjusted and non-adjusted models predicting c-AKI, AKI and RVF with IGFBP7, NT-pro-BNP and PAPi

Adjusted/unadjustedOutcomePredictor# Case–control pairsAUC (95% CI)AUC P value*Optimal cut-off point†SensitivitySpecificity
Unadjustedc-AKIIGFBP7 (ng/mL)170.81 (0.66 to 0.96)<0.001102 ng/mL0.820.76
NT-pro-BNP (pg/mL)180.51 (0.31 to 0.71)0.461295 pg/mL0.830.33
PAPi110.61 (0.36 to 0.87)0.191.080.640.64
AKIIGFBP7 (ng/mL)480.74 (0.64 to 0.84)<0.001102 ng/mL0.710.71
NT-pro-BNP (pg/mL)490.55 (0.44 to 0.67)0.21459 pg/mL0.490.69
PAPi380.57 (0.44 to 0.70)0.141.840.870.32
RVFIGFBP7 (ng/mL)500.65 (0.54 to 0.76)0.00489.5 ng/mL0.640.64
NT-pro-BNP (pg/mL)510.60 (0.49 to 0.71)0.041313 pg/mL0.750.51
PAPi320.51 (0.36 to 0.65)0.440.860.880.28
Adjustedc-AKIIGFBP7 (ng/mL)170.90 (0.81 to 1.00)<0.001--0.820.82
NT-pro-BNP (pg/mL)180.87 (0.76 to 0.99)<0.001--0.720.94
PAPi110.77 (0.56 to 0.97)0.004--0.730.73
AKIIGFBP7 (ng/mL)470.79 (0.67 to 0.88)<0.001--0.680.79
NT-pro-BNP (pg/mL)480.78 (0.68 to 0.87)<0.001--0.730.77
PAPi380.68 (0.56 to 0.81)0.003--0.340.97
RVFIGFBP7 (ng/mL)490.69 (0.58 to 0.80)<0.001--0.670.69
NT-pro-BNP (pg/mL)500.74 (0.64 to 0.83)<0.001--0.640.76
PAPi320.69 (0.56 to 0.82)0.002--0.340.97
  • *P values were derived from the sampling distribution of the AUC statistic, assuming normality and represent the proportion of the distribution lying at or below 0.5.

  • †Optimal cut-off points determined by maximising Youden’s index. Any ties were broken by minimising the distance to the upper left corner.

  • AKI, acute kidney injury; c-AKI, congestive AKI; NT-pro-BNP, N-terminal pro hormone B-type natriuretic peptide; PAPi, Pulmonary Artery Pulsatility Index; RVF, right ventricular failure.