Comparison of prior studies that have evaluated outcomes of as patients with baseline diastolic dysfunction after TAVR
| Study name | Author and journal | Study type | Study population | Main findings | Main difference from our study |
| Diastolic Function and Transcatheter Aortic Valve Replacement | John E.A. Blair et al. JASE, 2017. | Single centre retrospective cohort study. | 120 patients with severe AS who underwent TAVR. | Baseline diastolic dysfunction associated with increased mortality at 1 year. (HR, 1.163; 95% CI, 1.049 to 1.277, p=0.005) | Outcomes calculated only up to 1 year. Diastolic dysfunction not classified as per the 2016 JASE diastology guidelines. Included only 120 patients. |
| The Impact of Left Ventricular Diastolic Dysfunction on Clinical Outcomes After Transcatheter Aortic Valve Replacement | Masahiko Asami et al, JACC interventions, 2018. | Single centre retrospective cohort study. | 777 patients with AS who underwent TAVR. | Worsening grades of diastolic dysfunction associated with independent predictor of death at 1 year. | Outcomes calculated only up to 1 year. Patients with atrial fibrillation excluded. |
| Diastolic Function and Clinical Outcomes After Transcatheter Aortic Valve Replacement: PARTNER 2 SAPIEN 3 Registry | Geraldine Ong et al, JACC, 2020. | PARTNER 2 registry study. | 1253 patients with severe AS who underwent TAVR | Baseline DD was a predictor of up to 2 years clinical outcomes in patients who underwent TAVR. | Outcomes calculated only up to 2 years. Patients with atrial fibrillation excluded. |
| Association Between Diastolic Dysfunction and Health Status Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement | Ali O. Malik et al, JACC interventions, 2019. | Single centre retrospective cohort study. | 304 patients with severe AS who underwent TAVR | At 1 and 12 months after TAVR, LVDD was not associated with KCCQ-OS | Outcome measured only in terms of KCCQ score. No mortality or cardiovascular outcomes assessed. |
KCCQ-OS, Kansas City Cardiomyopathy Questionnaire Overall Summary Score; LVDD, left ventricular diastolic dysfunction; TAVR, transcatheter aortic valve replacement.