Table 3

Cox proportional hazards analysis

BaselineFollow-up
UnivariateMultivariateUnivariateMultivariate
HR (95% CI)P valueHR (95% CI)P valueHR (95% CI)P valueHR (95% CI)P value
PVR (WU)1.049 (1.014 to 1.085)0.0051.040 (0.979 to 1.104)0.2031.099 (1.058 to 1.140)<0.0011.103 (1.029 to 1.183)0.006
RAP (mm Hg)1.062 (0.998 to 1.130)0.0571.088 (0.987 to 1.199)0.0895.564 (1.325 to 23.372)0.0191.264 (1.098 to 1.455)0.001
WHO-FC IV2.973 (1.596 to 5.536)0.0013.054 (1.432 to 6.512)0.0042.341 (1.034 to 5.301)0.04113.167 (1.728 to 100.315)0.013
6-MWD (m)0.997 (0.994 to 0.999)0.0130.998 (0.995 to 1.000)0.0980.996 (0.993 to 1.000)0.0420.998 (0.993 to 1.003)0.473
BNP (pg/mL)1.001 (1.000 to 1.001)0.1121.000 (0.998 to 1.001)0.5171.003 (1.001 to 1.004)<0.0010.996 (0.993 to 1.000)0.037
Cardiac index (L/min/m2)0.750 (0.464 to 1.211)0.2391.303 (0.646 to 2.632)0.460.513 (0.331 to 0.796)0.0030.912 (0.392 to 2.125)0.831
  • BNP, B-type natriuretic peptide; 6-MWD, 6 min walk distance; N/A, not applicable; PVR, pulmonary vascular resistance; RAP, right atrial pressure; SVI, stroke vol index; WHO-FC, WHO functional class.