Association of CTRCD with overall or cause-specific death
| Unadjusted analysis | Adjusted analysis | |||
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Overall death | 3.30 (2.01 to 5.41) | <0.001 | 1.98 (1.11 to 3.52)* | 0.016 |
| Primary disease death | 3.91 (1.97 to 7.77) | <0.001 | 2.96 (1.40 to 6.29)† | 0.005 |
| Treatment-related death | 2.77 (1.35 to 5.69) | 0.005 | 1.78 (0.84 to 3.78)‡ | 0.131 |
*Adjusted for age, sex, CCr, primary disease type (leukaemia or not), CR status, source of HSCT (haploidentical PBSCT or not), HCT-CI (/point) and acute GVHD (/grade).
†Adjusted for age, sex, CCr, primary disease type (leukaemia or not), CR status, source of HSCT (haploidentical PBSCT or not), HCT-CI (/point).
‡Adjusted for age, sex, HCT-CI (/point) and acute GVHD (/grade).
CCr, creatinine clearance; CR, complete remission; CTRCD, cancer therapy-related cardiac dysfunction; GVHD, graft-versus-host disease; HCT-CI, haematopoietic cell transplantation-specific comorbidity index; PBSCT, peripheral blood stem cell transplantation.