Statin users (n=8631) | Statin non-users (n=8631) | |
General characteristics | ||
Age (years) | 61 (11) | 61 (13) |
Women (n, %) | 4482 (52) | 4499 (52) |
Ethnicity (n, %) | ||
Native Dutch | 6753 (78.2) | 6841 (79.3) |
First generation immigrant | 1297 (15.0) | 1200 (13.9) |
Second generation immigrant | 581 (6.7) | 590 (6.8) |
Annual personal income (€) | €27 860 (€14 647–€48 390) | €28 261 (€14 956–€47 613) |
Current smoker (n, %) | 3543 (41.0) | 3540 (41.0) |
10-year cardiovascular mortality risk (SCORE) | ||
0%–4% | 4757 (55.1) | 4562 (52.9) |
5%–9% | 2380 (27.6) | 2175 (25.2) |
≥10% | 1493 (17.3) | 1887 (21.9) |
Complaints (n, %) | ||
No of complaints | 3451 (40.0) | 3389 (39.3) |
0 | 4925 (57.1) | 5014 (58.1) |
1 | 235 (2.7) | 216 (2.5) |
2 | 20 (0.2) | 12 (0.1) |
≥3 | ||
Chest pain | 3176 (36.8) | 3158 (36.6) |
Dyspnoea | 778 (9.0) | 759 (8.8) |
Fatigue | 277 (3.2) | 273 (3.2) |
Heart murmurs | 77 (0.9) | 75 (0.9) |
Palpitations | 1088 (12.6) | 1141 (13.2) |
Collapse | 63 (0.7) | 76 (0.9) |
Comorbidities (n, %) | ||
Hypertension | 3386 (39.2) | 3310 (38.4) |
Diabetes mellitus | 843 (9.8) | 686 (7.9) |
Dyslipidaemia | 2078 (24.1) | 1957 (22.7) |
Cardiovascular diagnosis at baseline | 1061 (12.3) | 939 (10.9) |
Clinical characteristics | ||
Body mass index (kg/m2) | 27.0 (4.5) | 27.0 (4.7) |
Systolic blood pressure (mmHg) | 146 (21) | 146 (22) |
Total cholesterol (mmol/L) | 5.53 (1.29) | 5.62 (0.86) |
Low-density lipoprotein cholesterol (mmol/L) | 3.30 (2.50–4.20) | 3.30 (2.90–3.80) |
High-density lipoprotein cholesterol (mmol/L) | 1.40 (1.10–1.80) | 1.40 (1.10–1.80) |
Triglycerides (mmol/L) | 1.50 (1.00–2.20) | 1.50 (1.00–2.20) |
Estimated glomerular filtration rate (mL/min/1.73 m2) | 82 (27) | 82 (28) |
History of cardiovascular medication use | 970 (11.2) | 971 (11.3) |
Cardiovascular medication prescribed at baseline | 5798 (67.2) | 5807 (67.3) |
No of cardiovascular medications | ||
0 | 2256 (26.1) | 2240 (26.0) |
1–3 | 5316 (61.6) | 5457 (63.2) |
4–7 | 1048 (12.1) | 924 (10.7) |
8–10 | 11 (0.1) | 10 (0.1) |
Blood pressure lowering medication | 5388 (62.4) | 5352 (62.0) |
Antiplatelet or anticoagulant medication | 3086 (35.8) | 3032 (35.1) |
Other lipid-lowering medication | 187 (2.2) | 191 (2.2) |
Diabetes mellitus medication | 728 (8.4) | 572 (6.6) |
Nitrates | 859 (10.0) | 803 (9.3) |
Antiarrhythmic medication | 108 (1.3) | 121 (1.4) |
Digoxin | 62 (0.7) | 65 (0.8) |
Statin prescriptions at baseline (n, %) | ||
Statin name | ||
Atorvastatin | 1859 (21.5) | |
Fluvastatin | 42 (0.5) | |
Pravastatin | 643 (7.4) | |
Rosuvastatin | 889 (10.3) | |
Simvastatin | 5198 (60.2) | |
Statin intensity | ||
Lower than guideline recommended | 2805 (32.5) | |
Equal to guideline recommended | 3473 (40.2) | |
Higher than guideline recommended | 2353 (27.3) |
SCORE, Systematic COronary Risk Evaluation.