Baseline echocardiographic parameters
| Variable | Population (n=2011) | SMR without SAD (n=592) | SADMR (n=1419) | P value |
| LV end-diastolic volume, mL | 182.9±73.5 | 160.4±60.9 | 191.5±76.1 | <0.001 |
| LV end-systolic volume, mL | 124.3±59.6 | 108.2±48.2 | 130.4±62.3 | <0.001 |
| LV EF, % | 33.2±9.2 | 33.5±9.3 | 33.1±9.1 | 0.34 |
| MV mean gradient, mm Hg | 3.78±1.5 | 3.97±1.5 | 3.77±1.5 | 0.31 |
| MV peak gradient, mm Hg | 10.4±3.8 | 12±8.1 | 11.6±9 | 0.72 |
| MR Vmax, m/sec | 4.9±0.8 | 4.9±0.8 | 4.9±0.8 | 0.59 |
| EROA, mm2 | 41.7±26.1 | 41.2±29.4 | 41.9±24.7 | 0.63 |
| Mitral annulus calcification | 600 (30%) | 164 (28%) | 436 (31%) | 0.16 |
| SPAP, mm Hg | 50.8±15.1 | 49±15 | 52±15 | 0.001 |
| Moderate or severe RV dilation, % | 733 (36) | 170 (29) | 563 (40) | <0.001 |
| Moderate or severe RV dysfunction, % | 672 (33) | 181 (31) | 491 (35) | 0.09 |
| Moderate or severe tricuspid regurgitation, % | 1200 (60) | 300 (51) | 900 (63) | <0.001 |
| Diastology measurements | ||||
| Deceleration time, msec | 166.7±52.2 | 170.2±51.6 | 165.1±52.4 | 0.13 |
| Peak A velocity, cm/sec | 0.61±0.3 | 0.72±0.3 | 0.61±0.35 | <0.001 |
| Peak E velocity, cm/sec | 1.2±0.3 | 1.2±0.3 | 1.2±0.3 | 0.24 |
| E/A | 8.9±6.1 | 3.2±13.9 | 11.8±2.9 | 0.08 |
| E/e’ average ratio | 20.6±8.5 | 20.9±7.9 | 20.5±8.7 | 0.54 |
Significant p-values (<0.05) are highlighted in bold.
EF, ejection fraction; EROA, effective regurgitant orifice area; LV, left ventricle; MR, mitral regurgitation; MV, mitral valve; RV, right ventricle; SAD, severe atrial dilation mitral; SMR, secondary mitral regurgitation; SPAP, systolic pulmonary arterial pressure; Vmax, maximum velocity.