Entire cohort | PH group | P value | |||||
N=52 | No PH (n=5) | Pre-capillary PH (n=3) | IPC-PH (n=29) | CpcPH (n=15) | |||
Age (years) | 69±9 | 76±6 | 68±8 | 66±10 | 71±8 | 0.13 | |
Gender n (% male) | 44 (85%) | 4 (80%) | 3 (100%) | 26 (89.7%) | 11 (73.3%) | 0.45 | |
Ethnicity | White | 34 (65%) | 5 (100%) | 0 (0%) | 21 (72.4%) | 8 (53.3%) | 0.07 |
Black | 17 (33%) | 0 (0%) | 3 (100%) | 7 (24.1%) | 7 (46.7%) | ||
Other | 1 (2%) | 0 (0%) | 0 (0%) | 1 (3.4%) | 0 (0%) | ||
BMI (kg/m2) | 26.6 (24.1–30.9) | 23.9 (21.8–25.0) | 25.4 (23.7–28.8) | 28.2 (25.5–31.5) | 24.3 (23.2–32.2) | 0.04 | |
Amyloid subtype n (% ATTR) | 31 (60%) | 2 (40%) | 3 (100%) | 16 (55.2%) | 10 (66.7%) | 0.34 | |
Hypertension n (%) | 27 (52%) | 1 (20%) | 2 (66.7%) | 15 (51.7%) | 9 (60%) | 0.44 | |
Hyperlipidaemia n (%) | 28 (54%) | 1 (20%) | 0 (0%) | 18 (62.1%) | 9 (60%) | 0.08 | |
Diabetes n (%) | 11 (21%) | 0 (0%) | 1 (33.3%) | 6 (20.7%) | 4 (26.7%) | 0.60 | |
Congestive heart failure n (%) | 50 (96%) | 4 (80%) | 3 (100%) | 29 (100%) | 14 (93.3%) | 0.16 | |
NYHA class | I n (%) | 1 (2%) | 1 (20%) | 0 (0%) | 0 (0%) | 0 (0%) | 0.13 |
II n (%) | 19 (37%) | 3 (60%) | 2 (66.7%) | 10 (34.5%) | 4 (26.7%) | ||
III n (%) | 24 (46%) | 1 (20%) | 1 (33.3%) | 14 (48.3%) | 8 (53.3%) | ||
IV n (%) | 8 (15%) | 0 (0%) | 0 (0%) | 5 (17.2%) | 3 (20%) | ||
Creatinine (mg/dL) | 1.11 (0.93–1.38) | 1.05 (0.95–1.38) | 1.50 (1.30–1.59) | 1.09 (0.93–1.30) | 1.0 (0.88–1.46) | 0.43 | |
Haematocrit (%) | 38.2±5.0 | 38.3±2.1 | 31.0±3.9 | 37.6±5.4 | 40.0±3.9 | 0.05 | |
BNP (ng/L) | 518 (262–764) | 349 (213–785) | 518 (447–1017) | 520 (240–706) | 552 (304–849) | 0.84 | |
Troponin (ng/mL) | 0.18 (0.08–0.27) | 0.04 (0.04–0.40) | 0.16 (0.09–0.18) | 0.22 (0.08–0.30) | 0.18 (0.12–0.23) | 0.41 | |
Right atrial pressure (mm Hg) | 13.2±7.2 | 3.6±2.6* | 13.3±7.2 | 14.3±6.6*† | 14.1±7.4*† | 0.002 | |
Mean PA pressure (mm Hg) | 30.0±6.0 | 19.2±3.8* | 27.3±0.6 | 29.6±4.0*† | 35.0±5.1*† | <0.001 | |
Pulmonary capillary wedge pressure (mm Hg) | 19.9±5.5 | 9.4±3.0* | 13.7±0.6*† | 21.9±4.3*† | 20.8±3.8* | <0.001 | |
fick cardiac output (l/min) | 4.15±1.15 | 3.77±1.12 | 4.17±0.40 | 4.54±1.15 | 3.50±0.99 | 0.08 | |
Fick cardiac index (L/min/m2) | 2.1 (1.6–2.1) | 1.8 (1.7–2.7) | 2.0 (1.7–2.3) | 2.1 (1.8–2.4) | 1.7 (1.4–2.2) | 0.26 | |
PVR (mm Hg/L/min) | 2.6±1.2 | 2.7±0.5* | 3.3±0.4 | 1.7±0.6*† | 4.1±0.8*† | <0.001 | |
TPG (mm Hg) | 10.1±4.1 | 9.8±2.4* | 13.7±0.6 | 7.6±2.5† | 14.2±3.7*† | <0.001 | |
DPG (mm Hg) | 1 (0–3.8) | 3.0 (0.8–4.3) | 6.0 (5.0–6.8) | 0.0 (0.0–0.3)† | 3.0 (1.0–6.3)† | 0.003 |
Intergroup p-values are provided in online supplemental table 1.
*P<0.05 between no PH group and depicted PH group.
†P<0.05 between indicated PH groups.
ATTR, transthyretin; BMI, body mass index; BNP, B type natriuretic peptide; CpcPH, combined post and pre-capillary PH; DPG, diastolic pressure gradient; IPC-PH, isolated post-capillary PH; NYHA, New York Heart Association; PA, pulmonary arterial; PCWP, pulmonary capillary wedge pressure; PH, pulmonary hypertension; PVR, pulmonary vascular resistance; TPG, transpulmonary gradient.