Table 2A

Association between prior oral anticoagulant use and endpoints

EndpointPrior OACUnadjustedAdjusted*
Yes
KM% (events)
No
KM% (events)
HR (95% CI)
Prior OAC Yes vs No
P valueHR (95% CI)
Prior OAC Yes vs No
P value
Primary endpoint
ISTH major/CRNM bleeding
 At 30 days5.1 (111)5.9 (131)0.87 (0.67 to 1.12)0.270.82 (0.63 to 1.06)0.13
 At 180 days13.5 (282)13.5 (288)1.004 (0.85 to 1.18)0.960.98 (0.83 to 1.16)0.80
ISTH major bleeding
 At 30 days1.2 (30)1.8 (39)0.79 (0.49 to 1.27)0.330.65 (0.39 to 1.07)0.093
 At 180 days4.2 (86)4.3 (90)1.00 (0.74 to 1.34)0.990.90 (0.66 to 1.22)0.48
Intracranial bleeding
 At 30 days0.00 (0)0.2 (4)
 At 180 days0.5 (10)0.4 (9)1.13 (0.46 to 2.79)0.790.96 (0.38 to 2.40)0.92
Definite/probable stent thrombosis
 At 30 days0.5 (11)0.7 (16)0.71 (0.33 to 1.53)0.380.73 (0.33 to 1.59)0.43
 At 180 days0.6 (14)0.8 (18)0.801 (0.40 to 1.61)0.530.81 (0.40 to 1.66)0.57
All-cause death or rehospitalisaAtion
 At 30 days9.2 (208)10.8 (250)0.86 (0.71 to 1.030)0.0990.86 (0.71 to 1.04)0.11
 At 180 days26.3 (585)25.4 (580)1.04 (0.93 to 1.17)0.461.02 (0.90 to 1.14)0.80
All-cause death or ischaemic event
 At 30 days1.7 (38)2.8 (65)0.60 (0.40 to 0.90)0.0120.61 (0.41 to 0.92)0.019
 At 180 days5.4 (119)7.6(171)0.72 (0.57 to 0.91)0.0060.70 (0.55 to 0.88)0.003
Cardiovascular death
 At 30 days0.6 (13)0.9 (20)0.67 (0.33 to 1.35)0.260.70 (0.34 to 1.42)0.32
 At 180 days1.9 (43)2.9 (67)0.67 (0.46 to 0.98)0.040.61 (0.42 to 0.90)0.013
Stroke
 At 30 days0.2 (4)0.4 (9)0.46 (0.14 to 1.49)0.190.53 (0.16 to 1.74)0.29
 At 180 days0.8 (16)1.0 (23)0.71 (0.38 to 1.35)0.290.74 (0.39 to 1.43)0.37
Myocardial infarction
 At 30 days0.9 (21)1.7 (39)0.55 (0.33 to 0.94)0.0290.59 (0.34 to 1.01)0.053
 At 180 days2.8 (61)4.0 (89)0.72 (0.52 to 0.99)0.0440.73 (0.53 to 1.02)0.065
  • HRs in the ‘at 30 days’ rows include events from randomisation to 30 days. HRs in the ‘at 180 days’ rows include events from randomisation to 180 days.

  • *Adjusted by age, sex, race, hypertension, heart failure, diabetes, prior stroke, TIA or thromboembolism, qualifying index event and time from index event to randomisation.

  • CRNM, clinically relevant non-major; ISTH, International Society on Thrombosis and Haemostasis; KM, Kaplan-Meier; OAC, oral anticoagulation; TIA, transient ischaemic attack.