Baseline | Follow-up | P value | |
Cardiac MRI: left ventricle | |||
LVEDV (mL) | 171±36 | 169±38 | 0.57 |
LVESV (mL) | 54±20 | 52±20 | 0.41 |
SV (mL) | 117±22 | 117±23 | 0.98 |
EF (%) | 69±7 | 70±6 | 0.55 |
LVM (g) | 152±54 | 147±55 | 0.06 |
Native septal T1 (ms) | 1060±47 | 1049±42 | 0.06 |
ECV fraction (%) | 30.0±4.5 | 29.5±4.0 | 0.06 |
Total myocardial volume (mL) | 145±52 | 140±53 | 0.05 |
ECM volume (mL) | 44±18 | 42±17 | 0.04 |
Cellular volume (mL) | 101±36 | 99±37 | 0.11 |
Global longitudinal strain (%) | −18.3±3.4 | −19.4±3.4 | 0.03 |
PCr/ATP ratio | 1.27±0.44 | 1.4±0.39 | 0.46 |
Cardiac MRI: left atrium | |||
LAESV (mL) | 75.8±43.6 | 65.8±40.9 | 0.04 |
LAEDV (mL) | 124.4±51.3 | 114.6±47.3 | 0.18 |
Total EF (%) | 41.3±8.3 | 45.5±12.2 | 0.07 |
LA expansion index | 0.73±0.22 | 0.94±0.54 | 0.09 |
Total strain (%) | 20.0±3.9 | 21.5±5.0 | 0.04 |
Peak systolic strain rate (−1) | 0.75±13 | 0.83±0.19 | 0.11 |
Echocardiographic data | |||
E/A ratio | 1.11±0.67 | 1.10±0.50 | 0.84 |
Mean S’ velocity (cm/s) | 6.9±2.5 | 8.1±1.9 | 0.03 |
Mean E’ velocity (cm/s) | 6.8±3.4 | 7.0±2.5 | 0.71 |
Mean A’ velocity (cm/s) | 7.4±3.1 | 8.4±2.7 | 0.11 |
Mitral deceleration time (ms) | 295±79 | 265±47 | 0.11 |
ECV fraction was calculated as ECV = (1−haematocrit) x ƛ, where ƛ is the partition coefficient. Total myocardial volume was LV mass / 1.05. The total extracellular volume (ECM) was calculated with the formula ECM=ECV x LVM/1.05, while the cellular volume was calculated as cellular volume (mL)=total myocardial volume − ECM volume.
An expanded version of this table is available in the online supplemental tables S6, S7.
ECM, extracellular matrix; ECV, extracellular volume; EF, ejection fraction; LAEDV, left atrial end diastolic volume ; LAEF, left atrial ejection fraction; LVEDV, left vendricular end diastolic volume; LVESV, left ventricular end systolic volume ; LVM, left ventricular mass; PCr/ATP, myocardial phosphocreatine/adenosine triphosphate; SV, stroke volume.