Table 3

Adjusted HRs of primary and secondary outcomes

OutcomesNeitherMI onlyMB onlyBoth
HR (95% CI)P valueHR (95% CI)P valueHR (95% CI)P value
Primary 
All-cause mortalityReference1.63
(1.45 to 1.84)		<0.0012.11
(1.86 to 2.39)		<0.0012.92
(2.39 to 3.56)		<0.001
 Reference1.29
(1.10 to 1.52)		0.0011.79
(1.43 to 2.23)		<0.001
 Reference1.38
(1.10 to 1.73)		0.005
Secondary 
Cardiovascular mortalityReference2.18
(1.80 to 2.64)		<0.0011.83
(1.44 to 2.32)		<0.0013.72
(2.72 to 5.08)		<0.001
 Reference0.84
(0.63 to 1.11)		0.2221.70
(1.21 to 2.40)		0.002
 Reference2.03
(1.40 to 2.94)		<0.001

  • Due to Bonferroni correction to control for multiple pair-wise comparison, p value is significant only if it is less than 0.0083.

  • MI, myocardial infarction; MB, major bleeding.