Univariable and multivariable Cox proportional regression analysis for all-cause mortality and RELiEF TAVI score development
| Univariate and multivariate Cox proportional regression analysis (n=718) | RELiEF TAVI score | |||||
| Univariable analysis | Multivariable analysis (n=673) | β | Resulting points | |||
| HR (95% CI) | P value | HR (95% CI) | P value | |||
| Clinical parameters | ||||||
| Age | 1.00 (0.99 to 1.02) | 0.53 | ||||
| Male sex | 1.38 (1.11 to 1.71) | 0.0036 | 1.34 (1.06 to 1.68) | 0.013 | 1.00 | 1 |
| Underweight (BMI <18.5 kg/m2) | 2.86 (1.45 to 5.64) | 0.0025 | 3.10 (1.50 to 6.40) | 0.0022 | 3.90 | 4 |
| GFR <60 mL/min | 1.19 (0.95 to 1.48) | 0.13 | ||||
| Diabetes | 1.08 (0.87 to 1.35) | 0.46 | ||||
| COPD | 1.54 (1.23 to 1.95) | <0.001 | 1.55 (1.21 to 1.99) | <0.001 | 1.52 | 2 |
| Atrial fibrillation | 1.42 (1.15 to 1.75) | 0.0011 | 1.28 (1.03 to 1.60) | 0.028 | 0.86 | 1 |
| Prior stroke | 1.21 (0.93 to 1.57) | 0.16 | ||||
| Prior myocardial infarction | 1.07 (0.85 to 1.35) | 0.55 | ||||
| Echocardiography | ||||||
| SVI | 0.96 (0.95 to 0.98) | <0.001 | 0.96 (0.95 to 0.98) | <0.001 | 1.27* | 1 |
| LVEF | ||||||
| LVEF 45%–49% | 1 (reference) | |||||
| LVEF 30%–44% | 1.21 (0.93 to 1.57) | 0.16 | ||||
| LVEF <30% | 1.42 (1.09 to 1.84) | 0.0095 | ||||
| ≥Moderate TR | 1.33 (1.08 to 1.65) | 0.0085 | ||||
| ≥Moderate MR | 1.00 (0.81 to 1.23) | 0.99 | ||||
| Pulmonary hypertension (sPAP >55 mm Hg) | 1.53 (1.19 to 1.96) | <0.001 | 1.51 (1.17 to 1.94) | 0.0015 | 1.42 | 1 |
| CT | ||||||
| Non-TF access | 1.40 (1.10 to 1.80) | 0.0071 | 1.36 (1.05 to 1.76) | 0.021 | 1.05 | 1 |
| Low AVCd† | 1.33 (1.08 to 1.65) | 0.0081 | 1.44 (1.15 to 1.79) | 0.0012 | 1.25 | 1 |
| ≤10 mm3 LVOT calcium | 1.16 (0.92 to 1.45) | 0.21 | ||||
Abbreviations as in table 1.
*Statistically derived cut-off: SVI ≤24.9 mL/m2.
†Male cut-off: ≤62.45 mm3 calcium/cm2, female cut-off: ≤51.04 mm3 calcium/cm2.
AVCd, aortic valve calcification density; BMI, body mass index; COPD, chronic obstructive pulmonary disease; GFR, glomerular filtration rate; LVEF, left ventricular ejection fraction; LVOT, left ventricular outflow tract; MR, mitral regurgitation; RELiEF TAVI, Risk prEdiction in patients with Low Ejection Fraction low gradient aortic stenosis undergoing TAVI; sPAP, systolic pulmonary artery pressure; SVI, stroke volume index; TAVI, transcatheter aortic valve implantation; TF, transfemoral; TR, tricuspid regurgitation.