Table 1

Survivor characteristics

VariableAllo-HSCTControlsP value
Number10355
Gender (female)55 (53.4)29 (52.7)0.936
Body mass index (kg/m2)24.5±5.124.1±3.40.478
Age at allo-HSCT (years)17.6±9.5
Time to follow-up (years)17.2±5.5
Age at examination (years)34.8±11.636.4±10.60.401
Systolic blood pressure (mm Hg)123±19117±11*0.036
Diastolic blood pressure (mm Hg)72±1366±8*<0.001
Heart rate (bpm)69±1168±120.59
Malignant/non-malignant disease76 (73.8)/27 (26.2)
Mediastinal radiotherapy2 (1.9)
Anthracyclines46 (44.7)
 Cum. dosage (mg/m2)270 (130, 435)
Myeloablative conditioning:
 Chemotherapy (Bu/Cy)94 (91.3)
 Chemotherapy+TBI7 (6.8)
 None2 (1.9)
Graft-versus-host disease (GVHD)67 (65.0)
 Acute GVHD27 (26.2)
 Chronic GVHD12 (11.7)
 Acute and chronic GVHD28 (27.2)
New York Heart Association
 Class-I74 (73.3)†55 (100.0)<0.001
 Class-II16 (15.8)†0 (0)0.002
 Class-III11 (10.7)†0 (0)0.008
 Class-IV0 (0)†0 (0)
Risk factors:
 Hypertension41 (39.8)1 (1.8)<0.001
 Diabetes mellitus3 (2.9)0 (0)0.552
 Hypothyroidism9 (8.7)0 (0)0.028
 Hypercholesterolaemia15 (14.9)†0 (0)0.003
 Bronchiolitis obliterans syndrome10 (9.7)0 (0)0.015
 Smoking (current/previous)10 (9.9)/17 (16.5)†2 (3.6)/11 (20.0)0.216/0.622
Laboratory parameters:
 NT-pro-BNP (ng/L)§47 (22, 84)5 (5,52)¶<0.001
 Elevated levels**16 (15.5)2 (4.0)¶0.038
  • Data presented as mean±SD, median (25th, 75th) or n (%). Calculated with Student’s t-test, Mann-Whitney and χ2/Fisher’s exact test. Statistically significant values in boldface p<0.05.

  • *n=54.

  • †n=101.

  • §Lowest recordable value=5 ng/L.

  • ¶n=50.

  • **18–44 years: male >86 ng/L, female >130 ng/L, 45–54 years: male >121 ng/L, female >249 ng/L.

  • allo-HSCT, allogeneic haematopoietic stem-cell transplantation; NT-pro-BNP, N-terminal pro-brain-type natriuretic peptide; TBI, total body irradiation.