Myocardial injury and function measured by CMR according to IL-6 values
| All patients | Before PCI | After PCI | Day 1 | 4 months | |||||||||
| IL-6<median | IL-6>median | P value | IL-6<median | IL-6>median | P value | IL-6<median | IL-6>median | P value | IL-6<median | IL-6>median | P value | ||
| CMR in acute phase | |||||||||||||
| Infarct size (% of LV mass) | 17.3 | 15.5 | 19.0 | 0.02 | 15.4 | 19.2 | 0.04 | 13.5 | 23.3 | <0.001 | |||
| LV ejection fraction (%) | 51 | 54 | 49 | <0.001 | 53 | 49 | <0.001 | 54 | 47 | <0.001 | |||
| Presence of MVO | 49.8% | 47% | 54% | 0.23 | 46% | 53% | 0.29 | 37% | 65% | <0.001 | |||
| CMR after 4 months | |||||||||||||
| Infarct size (% of LV mass) | 13.9 | 12.1 | 16.1 | 0.01 | 13.1 | 16.1 | 0.03 | 11.0 | 17.2 | <0.001 | 13.5 | 15.6 | 0.02 |
| Myocardial Salvage (%) | 51.9 | 51.9 | 51.5 | 0.60 | 51.9 | 52.1 | 0.56 | 58.1 | 44.7 | <0.001 | 53.8 | 50.3 | 0.47 |
| LV ejection fraction (%) | 55 | 58 | 53 | 0.003 | 58 | 54 | 0.005 | 59 | 53 | <0.001 | 58 | 53 | 0.004 |
| ∆EDVi (mL/m2) | 4.5 | 2.3 | 6.2 | 0.04 | 2.2 | 6.2 | 0.04 | 1.0 | 8.1 | 0.001 | 4.5 | 4.1 | 0.41 |
Data are presented as median or percentage. IL-6 was measured before and immediately after the PCI-procedure, at day 1 (median 18.3 hours after PCI) and at 4-month follow-up in 261 patients with ST-elevation myocardial infarction.
Significant values are highlighted in bold.
CMR, cardiac MRI; ∆EDVi, change in end-diastolic volume (indexed for BSA) of LV from the acute phase to 4 months; IL, interleukin; LV, left ventricle; MVO, microvascular obstruction; PCI, percutaneous coronary intervention.