Concentrations of inflammatory, coagulation, renal and cardiac biomarkers and presence of SARS-CoV-2 viraemia by quartiles (Q) of baseline sST2 concentrations
| sST2 Q1 | sST2 Q2 | sST2 Q3 | sST2 Q4 | P value for trend | Rho | |
| n=31 | n=31 | n=31 | n=30 | |||
| White cell count, × 109/L | 5.0 (3.8, 7.2) | 5.7 (4.4, 7.6) | 6.1 (4.8, 9.5) | 7.9 (6.2, 10.5) | <0.001 | 0.36 |
| Lymphocyte count, × 109/L | 1.1 (0.8, 1.5) | 1.0 (0.8, 1.4) | 0.9 (0.7, 1.3) | 0.8 (0.6, 1.0) | 0.005 | −0.28 |
| Interleukin-6 (pg/mL) | 23 (11, 47) | 33 (16, 48) | 41 (22, 63) | 95 (43, 159) | <0.001 | 0.43 |
| C reactive protein (mg/L) | 34 (17, 50) | 60 (25, 130) | 100 (48, 150) | 120 (60, 220) | <0.001 | 0.42 |
| Procalcitonin (µg/L) | 0.06 (0.04, 0.14) | 0.10 (0.06, 0.21) | 0.15 (0.08, 0.21) | 0.33 (0.18, 0.77) | <0.001 | 0.62 |
| Ferritin (µg/L) | 299 (156, 543) | 326 (171, 639) | 540 (325, 1042) | 990 (362, 1960) | <0.001 | 0.40 |
| Lactate dehydrogenase | 260 (210, 310) | 255 (220, 390) | 330 (250, 450) | 360 (270, 550) | <0.001 | 0.33 |
| D-dimer (mg/L) | 0.3 (0.3, 0.5) | 0.6 (0.4, 1.2) | 0.6 (0.4, 0.9) | 0.8 (0.5, 1.2) | <0.001 | 0.37 |
| eGFR (mL/min/1.73 m2) | 98 (80, 109) | 90 (84, 107) | 89 (55, 107) | 70 (37, 94) | <0.001 | −0.32 |
| Cardiac troponin T (ng/L) | 6 (4, 9) | 7 (4, 14) | 11 (6, 17) | 18 (8, 29) | <0.001 | 0.43 |
| NT-proBNP (ng/L) | 60 (36,154) | 54 (20, 213) | 109 (40, 265) | 256 (121, 466) | <0.001 | 0.36 |
| SARS-CoV-2 viraemia, n (%) | 10 (32.3) | 8 (25.8) | 11 (35.5) | 19 (63.3) | 0.009 |
Concentrations are reported as median (Q1, Q3). Coefficient of correlations between biomarkers as continuous variables are given as Spearman rho. All correlations had p<0.001.
eGFR, estimated glomerular filtration rate; NT-proBNP, N-terminal pro-B-type natriuretic peptide; sST2, soluble ST2.