Comparisons of right ventricular function in survivors and controls
| Variable | Allo-HSCT (n=103) | Control (n=55) | P value | Adjusted P value* |
| RA morphology | ||||
| RA area (cm/m2) | 8.0±1.5 | 8.3±1.4 | 0.254 | 0.445 |
| RA-EDV-index (mL/m2) | 22.2±6.8 | 22.8±4.9 | 0.560 | 0.833 |
| Dilated RA-EDV† | 14 (13.6) | 5 (9.1) | 0.407 | |
| RV morphology | ||||
| RVIDd basal (cm/m2) | 2.0±0.3 | 2.0±0.2 | 0.133 | 0.092 |
| RVIDd mid-wall (cm/m2) | 1.7±0.3 | 1.6±0.2 | 0.005 | 0.001 |
| RVIDs basal (cm/m2) | 1.6±0.2 | 1.5±0.2 | 0.391 | 0.158 |
| RVIDs mid-wall (cm/m2) | 1.3±0.2 | 1.1±0.2 | 0.001 | <0.001 |
| RV length (cm/m2) | 4.1±0.5 | 3.9±0.4 | 0.119 | 0.145 |
| RV wall-thickness (mm) | 39±4 (n=90) | 38±4 (n=48) | 0.111 | 0.168 |
| RV-EDA (cm/m2) | 11.0±2.3 | 10.8±1.0 | 0.538 | 0.428 |
| Dilated RV-EDA‡ | 32 (31.1) | 9 (6.4) | 0.045 | - |
| RV-ESA (cm/m2) | 6.5±1.4 | 6.2±1.1 | 0.227 | 0.068 |
| RV function | ||||
| Fractional area change (%) | 41.0±5.2 | 42.2±5.1 | 0.175 | 0.047 |
| FAC <35% | 11 (10.7) | 2 (3.6) | 0.222 | - |
| TAPSE (mm) | 20.8±3.7 | 24.6±3.8 | <0.001 | <0.001 |
| TAPSE <17mm | 13 (13.0) | 1 (1.8) | 0.020 | - |
| RV s’ (cm/s) | 11.1±2.3 | 12.3±2.3 | 0.005 | 0.001 |
| RV-s’ <9.5cm/s | 26 (25.5) | 8 (14.8) | 0.124 | - |
| RV-e’ (cm/s) | 10.0±2.7 | 11.7±2.5 | <0.001 | <0.001 |
| RV-e’ <7.8cm/s | 18 (17.6) | 1 (1.9) | 0.004 | - |
| RIMP | 0.45±0.09 | 0.45±0.07 | 0.851 | 0.649 |
| RIMP >0.54 | 17 (17.2) | 3 (5.6) | 0.042 | - |
| RVFWS (%) | −27.1±4.2 | −28.5±3.3 | 0.052 | 0.043 |
| RVFWS ≥20% | 3 (3.2) | 0 (0) | 0.553 | - |
| TRP (mm Hg) | 18.1±4.0 | 16.7±2.6 | 0.034 | 0.125 |
| PASP >35 mm Hg | 3 (2.9) | 0 (0) | 0.552 | - |
| LV function | ||||
| 2D-LVEF (%) | 55.2±5.9 | 59.0±2.9 | <0.001 | <0.001 |
| GLS (%) | −17.5±2.2 | −19.7±1.4 | <0.001 | <0.001 |
| E/e' | 6.6±2.2 | 5.7±1.4 | 0.003 | 0.011 |
*Adjusted p values by propensity scoring. Statistically significant values in boldface (p<0.05).
†Dilated RA in males if >32 mL/m2 and in females if >27 mL/m2.
‡Dilated RV-EDA in males if >12.6 cm2/m2 and in females if >11.5 cm2/m2.
Allo-HSCT, allogeneic haematopoietic stem-cell transplantation; 2D, two dimensions; E/e', ratio of early-diastolic velocity to mean early-diastolic myocardial velocity; FAC, fractional area change; GLS, global longitudinal strain; LVEF, left ventricular ejection fraction; PASP, pulmonary arterial systolic pressure; RA, right atrium; RA-EDV, RA-end-diastolic volume; RIMP, Right Ventricular Index of Myocardial Performance; RV, right ventricular; RV-e', RV early-diastolic velocity; RV-EDA, RV-end-diastolic area; RV-ESA, RV-End-Systolic Area; RVFWS, RV-free-wall strain; RVIDd, RV-internal dimension in diastole; RVIDs, RV-internal dimension in systole; RV-s', RV-peak systolic velocity; TAPSE, tricuspid annular plane systolic excursion; TRP, tricuspid regurgitation pressure.