Table 2

Multivariable Cox proportional hazards regression analyses for predictors of death in all patients, and patients with and without atrial fibrillation (AF)

Analysis	All patients (n=165 184)		AF patients (n=12 450)		Non-AF patients (n=152 734)
Parameters	HR	P value	HR	P value	HR	P value
Parameters	(95% CI)	P value	(95% CI)	P value	(95% CI)	P value
CHA₂DS₂-VASc score	1.23 (1.21 to 1.25)	<0.001	1.21 (1.16 to 1.26)	<0.001	1.23 (1.21 to 1.26)	<0.001
Atrial fibrillation	1.18 (1.10 to 1.27)	<0.001	N/A	N/A	N/A	N/A
Smoking history	1.65 (1.58 to 1.73)	<0.001	1.45 (1.30 to 1.62)	<0.001	1.69 (1.61 to 1.77)	<0.001
End-stage renal disease	2.33 (2.10 to 2.59)	<0.001	2.12 (1.71 to 2.64)	<0.001	2.43 (2.15 to 2.73)	<0.001
Anticoagulation	1.50 (1.40 to 1.60)	<0.001	1.21 (1.08 to 1.36)	<0.001	1.63 (1.51 to 1.77)	<0.001
Aspirin	1.08 (1.03 to 1.13)	0.001	0.97 (0.86 to 1.09)	0.569	1.08 (1.03 to 1.14)	0.001
Statin	0.85 (0.81 to 0.9)	<0.001	0.83 (0.74 to 0.94)	0.003	0.86 (0.92 to 0.91)	<0.001
Metabolic equivalents of task	0.73 (0.72 to 0.74)	<0.001	0.74 (0.72 to 0.76)	<0.001	0.73 (0.72 to 0.74)	<0.001

CHA2DS2-VASc, congestive heart failure, hypertension, age, diabetes mellitus, stroke or transient ischemic attack, vascular disease, sex; N/A, not applicable.