Table 1

Patient characteristics

TAVR (n=137)SAVR (n=137)P value
Age (years)82.7±6.472.5±7.6<0.001
Female gender59 (43.1)43 (31.4)0.046
Body mass index (kg/m2)27.7±5.028.4±4.90.209
Cardiac disease
Coronary artery disease65 (47.4)14 (10.2)<0.001
 Previous myocardial infarction11 (8.7)2 (1.5)0.007
 Percutaneous coronary intervention31 (22.6)11 (8.0)0.001
 Coronary artery bypass graft15 (10.9)0 (0)<0.001
History of atrial fibrillation48 (36.4)20 (14.9)<0.001
Pacemaker/ICD implantation15 (10.9)6 (4.4)0.041
Previous hospital admission due to CHF48 (37.2)13 (9.8)<0.001
Aortic and/or peripheral vascular surgery1 (0.8)3 (2.2)0.623
Mitral valve intervention2 (1.6)1 (0.7)0.613
Tricuspid valve intervention2 (1.6)1 (0.7)0.613
Comorbidities
Carotid artery stenosis (>50%)12 (8.8)4 (3.0)0.030
Cerebrovascular disease17 (12.6)4 (2.9)0.003
Peripheral vascular disease15 (11.3)4 (3.0)0.008
Diabetes mellitus36 (26.3)31 (22.6)0.482
Pulmonary disease23 (17.0)19 (13.9)0.470
Pulmonary hypertension (sys >60 mm Hg)8 (7.0)5 (4.3)0.383
Renal insufficiency/failure
 Creatinine ≥2.0 mg/dL8 (5.8)1 (0.7)0.036
 Dialysis1 (0.7)0 (0)1.000
Current smoker2 (1.5)6 (4.4)0.282
Present diagnosis of a psychiatric diagnosis, anxiety disorder or depression (being actively treated)4 (2.9)6 (4.4)0.519
Risk scores, mean±SD
Euroscore II4.18±3.581.68±1.75<0.001
STS risk score5.22±4.742.45±2.69<0.001
MMSE-225.2±5.327.1±3.10.001
Katz5.65±0.975.96±0.27<0.001
IADL6.39±1.927.36±1.20<0.001
 Female5.88±2.107.58±0.91<0.001
 Male6.77±1.677.27±1.310.030
Baseline health status, mean±SD
TASQ overall summary67.1±19.475.3±17.7<0.001
TASQ physical symptoms8.1±2.58.9±2.80.015
TASQ physical limitations13.5±5.716.1±5.8<0.001
TASQ emotional impact30.8±10.333.1±9.80.061
TASQ social limitations9.1±4.211.3±3.3<0.001
TASQ health expectations5.6±1.45.9±1.40.122
KCCQ overall summary52.4±22.468.1±19.6<0.001
KCCQ physical limitations55.1±26.275.1±20.7<0.001
KCCQ total symptoms61.5±23.871.9±21.8<0.001
KCCQ quality of life44.9±23.355.2±22.7<0.001
KCCQ social limitation48.5±28.970.2±26.5<0.001
SF-12v2 physical summary36.9±7.242.4±9.3<0.001
SF-12v2 mental summary47.0±10.950.0±9.90.018
  • MMSE-2 score: 0–30 (the higher, the better); Katz activities of daily living score: 0 (dependent)–6 (independent); IADL score: 0 (low function, dependent)–8 (high function, independent).

  • CHF, congestive heart failure; IADL, instrumental activities of daily living; ICD, implantable cardioverter–defibrillator; KCCQ, Kansas City Cardiomyopathy Questionnaire; MMSE, Mini Mental State Examination; SAVR, surgical aortic valve replacement; SF-12v2, Short Form-12 V.2; STS, Society of Thoracic Surgeons; TASQ, Toronto Aortic Stenosis Quality of Life Questionnaire; TAVR, transcatheter aortic valve replacement.