Per-lesion adverse plaque characteristics by artificial intelligence enabled quantitative coronary computed tomographic angiography by non-obstructive versus obstructive angiographic stenosis stratified by age
| Variable | Non-obstructive (<50%) per-lesion | Obstructive (≥50%) per-lesion | ||||
| Age <65 (N=71) | Age ≥65 (N=116) | P value | Age <65 (N=77) | Age ≥65 (N=98) | P value | |
| PV, mm3 | 60.5 (79.8) | 105.6 (140.5) | 0.001 | 103.8 (134.5) | 109.7 (131.4) | 0.83 |
| LD-NCP, mm3 | 1.6 (3.1) | 2.0 (6.6) | 0.56 | 4.2 (8.2) | 2.6 (10.0) | 0.26 |
| NCP, mm3 | 38.4 (50.8) | 56.2 (75.8) | 0.058 | 74.6 (108.1) | 61.5 (85.8) | 0.33 |
| CP, mm3 | 22.1 (39.1) | 49.4 (86.8) | 0.004 | 29.2 (51.5) | 48.2 (72.7) | 0.04 |
| PAV (total plaque) | 41.0 (17.4) | 44.8 (16.8) | 0.17 | 49.9 (18.6) | 54.7 (16.5) | 0.07 |
| % PAV (LD-NCP) | 1.5 (3.3) | 0.7 (1.3) | 0.038 | 2.0 (3.0) | 1.2 (2.8) | 0.12 |
| % PAV (NCP) | 25.6 (12.4) | 25.2 (12.9) | 0.81 | 33.1 (19.3) | 30.5 (15.4) | 0.32 |
| % PAV (CP) | 13.7 (15.7) | 18.6 (18.1) | 0.07 | 13.9 (15.6) | 30.5 (15.4) | 0.001 |
| % Plaque calcified | 28.0 (28.5) | 36.8 (28.9) | 0.06 | 27.3 (26.8) | 38.2 (27.3) | 0.007 |
| Remodelling index | 1.13 (0.20) | 1.06 (0.21) | 0.02 | 1.10 (0.28) | 1.05 (0.28) | 0.24 |
| Positive remodeling >1.1 | 29 (41%) | 34 (29%) | 0.36 | 25 (33%) | 29 (30%) | 0.78 |
| Intermediate remodelling | 28 (39%) | 46 (40%) | 26 (34%) | 27 (28%) | ||
| Negative remodelling | 14 (20%) | 36 (31%) | 26 (34%) | 42 (43%) | ||
| HRP (LD-NCP +PR) | 34 (48%) | 42 (36%) | 0.16 | 31 (40%) | 33 (34%) | 0.40 |
| Lesion length, mm | 13.9 (10.4) | 18.1 (15.6) | 0.02 | 18.3 (15.5) | 18.2 (15.1) | 0.90 |
CP, calcified plaque; HRP, high risk plaque; LD-NCP, low-density non-calcified plaque; NCP, non-calcified plaque; PAV, per cent atheroma volume; PR, positive remodelling ; PV, plaque volume.