Table 3

Standardised 90-day all-cause mortality risks in relation to diagnostic work-up

Diagnostic modalityDiagnostic work-upDiagnostic work-upP value
PerformedNot performed
CCTA, risk (95% CI)3.9% (0.4% to 7.3%)6.2% (5.2% to 7.1%)0.21
CAG, risk (95% CI)4.3% (3.0% to 5.6%)7.4% (5.9% to 8.8%)0.004
PET-CT, risk (95% CI)0.0% (0.0% to 0.0%)6.1% (5.1% to 7.0%)<0.001
CMR, risk (95% CI)6.3% (1.4% to 11.3%)6.1% (5.1% to 7.0%)0.92
EMB, risk (95% CI)15.1% (8.2% to 22.1%)5.8% (4.9% to 6.7%)0.009
PET-CT or CMR or EMB, risk (95% CI)9.4% (4.9% to 13.9%)5.9% (4.9% to 6.8%)0.13
CMR or EMB, risk (95% CI)9.5% (5.0% to 14.1%)5.9% (4.9% to 6.8%)0.13
  • Number of patients who had the specific diagnostic work-up modalities performed can be found in table 1, and the comparator consists of the acute myocarditis population (n=2523) minus the number of the patients who had the diagnostic modality performed. The reported absolute risks for patients with acute myocarditis versus population controls standardised to the age, sex and comorbidity distribution of all patients were derived from multivariable Cox regression. The following covariates were included in the models: patient age, sex, hypertension, diabetes, chronic obstructive pulmonary disease, prior myocardial infarction, prior ischaemic heart disease, percutaneous cardiac intervention, coronary artery bypass grafting, stroke, peripheral artery disease, atrial fibrillation or flutter, heart failure, prior ventricular tachycardia/ventricular fibrillation/arrest and chronic kidney disease.

  • CAG, coronary angiogram; CCTA, coronary CT angiography; CMR, cardiac magnetic resonance; EMB, endomyocardial biopsy; PET-CT, positron emission tomography CT.